NewblueCHEM-- 1401-69-0--High purity TYLOSIN factory price

TYLOSIN

English Synonyms: TYLOCINE (R); TYLOSIN; fradizine; tylocine; Tylosine; TYLAN50; Tylosin (base and / or unspecified salts); N, N-Tylozine

CAS number: 1401-69-0

Molecular formula: C46H77NO17

Molecular weight: 916.1

EINECS No. 215-754-8

Related Categories: Carbohydrates & Derivatives; Chiral Reagents; Intermediates & Fine Chemicals; Pharmaceuticals; APIs; Antibiotics; PROHANCE; Microbial Metabolites; Macrolide Antibodies; Small Molecules Inhibitors;

Mol File: 1401-69-0.mol

Tylosin

Tylosin nature

Mp 135-137 ° C

Specific rotation D25 -46 ° (c = 2 in methanol)

Storage conditions 2-8 ° C

EPA chemical information Tylosin (1401-69-0)

Tylosin use and synthesis method

Antibiotics tylosin is currently used in China as a kind of macrolide antibiotics, also known as Thai farmers, tylosin, by the actinomycetes Streptomyces spp. By fermentation extraction obtained Tylorus Alkali, phosphate and tartrate three kinds of morphology. Antibacterial spectrum and erythromycin similar to Gram-positive bacteria and some Gram-negative bacteria, mycoplasma, Vibrio, coccidia, spirochetes, etc. are inhibited, particularly effective for mycoplasma, but the role of Gram-positive bacteria Not as good as erythromycin. This product is characterized by a strong role of mycoplasma, macrolides in the anti-mycoplasma most one of the drugs. As a feed additive, it is widely used in the feedstuffs of chickens, pigs, cattle, sheep, fish, shrimp and other animals, which can promote the growth of livestock and poultry and improve the feed utilization rate. Mainly for the control of chickens, turkeys and other animals mycoplasma disease; Vibrio swine fever, infectious pleuropneumonia, also used for sensitive bacteria caused by enteritis, pneumonia, mastitis, endometritis and so on. Chronic respiratory disease treatment of chicken, subcutaneous injection is better than oral administration, subcutaneous injection of tissue drug concentration 2 to 3 times higher than oral administration, effective blood drug concentration to maintain a longer time. In addition, tylosin phosphate also used as cattle, pigs, chicken growth-promoting drug feed additives. This product exists cross-resistance with erythromycin.

In 1962, Eli Lilly and Company successfully developed and introduced tylosin into the market, which is mainly used for feed additives and animal treatment. It can obviously promote the growth of livestock and poultry and improve the feed utilization rate, and mainly exist in the form of tylosine , In the body with the prokaryotic ribosome binding, hinder the amino acid peptide chain synthesis, thereby inhibiting the synthesis of infected bacterial protein, strong tissue penetration, oral absorption quickly, the distribution of tissues (the highest amount produced in the lungs, Liver, kidney, spleen and gallbladder), high bioavailability, rapid onset, effective inhibitory concentration to maintain a long time, excretion after stopping fast, less residue, high safety. Active ingredients accurate, wide range of safety, low toxicity. It is stable in nature, less susceptible to damage by the environment, dilutions and feedstuffs, and has a minimal effect on the active ingredients of the feed. Tylosin has a good growth-promoting effect, continuous low-dose, not only to prevent disease, but also significantly promote animal growth and shorten the breeding cycle. Tylosin is a livestock-specific antibiotic that avoids cross-resistance problems that are common to humans and animals in sharing antibiotics.