2,4,5,6-Tetraaminopyrimidine sulfate

Details:

1. Introduction of 2,4,5,6-Tetraaminopyrimidine sulfate

2,4,5,6-Tetraaminopyrimidine sulfate with the cas register number of 5392-28-9. It also can be called Pyrimidine, tetraamino-, sulfate (1:1) ; 2,4,5,6-Pyrimidinetetramine, sulfate (1:1) ; and Pyrimidinetetramine, sulfate (1:1) . Its IUPAC name is pyrimidine-2,4,5,6-tetramine. The product category of it is 2,4,5,6-Tetraaminopyrimidine sulfate (CAS NO.5392-28-9): Amines;(intermediate of methotrexate);Pyrimidines;Heterocyclic Building Blocks.

2. Basic Information of 2,4,5,6-Tetraaminopyrimidine sulfate

1) Properties

Melting point: >300 °C(lit.)
Flash Point: 329.4 °C
Boiling Point: 563.9 °C at 760 mmHg
Vapour Pressure: 9.68E-13 mmHg at 25 °C
Water Solubility: slightly soluble
Appearence: Light yellow crystal powder

2) Descriptors of Structure

Canonical SMILES: C1(=C(N=C(N=C1N)N)N)N.OS(=O)(=O)O
InChI: InChI=1S/C4H8N6.H2O4S/c5-1-2(6)9-4(8)10-3(1)7;1-5(2,3)4/h5H2,(H6,6,7,8,9,10);(H2,1,2,3,4)
InChIKey: MQEFDQWUCTUJCP-UHFFFAOYSA-N
 

3) Safety Profile
Safety: WARNING: Irritates lungs, eyes, skin
Hazard Codes: Xi (Irritant)
Risk Statements: 36/37/38 (Irritating to eyes, respiratory system and skin)
Safety Statements: 22-24/25-37/39-26-36 (Do not breathe dust; Avoid contact with skin and eyes; Wear suitable protective clothing and eye/face protection; In case of contact with eyes, rinse immediately with plenty of water and seek medical advice; Wear suitable protective clothing)
WGK Germany: 3
RTECS: UV9738000

 

4) Standards and Recommendations
ASSAY: 98.0% min
RESIDUE ON IGNITION: 0.3% max
MOISTURE: 0.5% max

5) Uses
2,4,5,6-Tetraaminopyrimidine sulfate (CAS NO.5392-28-9) is used as the intermediate of antineoplastic agent.
 

6) Production
2,4,5,6-Tetraaminopyrimidine sulfate (CAS NO.5392-28-9) can be obtained by nitrosification and reduction of 2,4,6-Triaminopyrimidine .
 

7) Other information
2,4,5,6-Tetraaminopyrimidine sulfate (CAS NO.5392-28-9) should be stored in cool, dry conditions in well sealed containers. It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately. Notes to physician: Treat supportively and symptomatically.