TIANFU-CHEM - Fing...

TIANFU-CHEM - Fingolimod hydrochloride

TIANFU-CHEM - Fingolimod hydrochloride

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1 Gram

FOB Price: USD 1000.0000

  • Min.Order :1 Gram
  • Purity: 99.0%
  • Payment Terms : L/C,D/A,D/P,T/T,,MoneyGram,Other

Keywords

Fingolimod hydrochloride 162359-56-0 C19H34ClNO2

Quick Details

  • Appearance:Solid
  • Application:Organic synthesis
  • PackAge:IN 25kg drums
  • ProductionCapacity:10|Metric Ton|Month
  • Storage:In Room Temperature
  • Transportation:As per MSDS

Superiority:

Henan Tianfu Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license.

We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the company is to put quality first and put our customer’s needs first - the satisfaction of our customers is the company's ultimate goal.

Improving product quality and service level is our responsibility, and creating more value for our customer’s is our purpose. We are constantly striving to make Henan Tianfu a leading chemical supplier, and hope to create a better future with you.

Details:

Fingolimod hydrochloride Basic information
Oral drug for the treatment of multiple sclerosis
Product Name: Fingolimod hydrochloride
Synonyms: Fingolimod (FTY720) hydrochloride;Fin;limod hydrochloride;fingolimod hydrochloride;FTY720;2-AMINO-2-[2-(4-OCTYLPHENYL)ETHYL]-1,3-PROPANEDIOL, HYDROCHLORIDE;2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride;Fingolimod HCl
CAS: 162359-56-0
MF: C19H34ClNO2
MW: 343.93
EINECS:
Product Categories: All Inhibitors;Inhibitors;Metabolites;Pharmaceutical intermediate;Pharmaceuticals;Aromatics;Intermediates & Fine Chemicals;Metabolites & Impurities;API;Other APIs
Mol File: 162359-56-0.mol
Fingolimod hydrochloride Structure
Fingolimod hydrochloride Chemical Properties
Melting point 102-107°C
storage temp. -20°C Freezer
solubility water: soluble10mg/mL, clear
color white to beige
Merck 14,4083
CAS DataBase Reference 162359-56-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38-52/53
Safety Statements 26-61
RTECS TY3130000
MSDS Information
Fingolimod hydrochloride Usage And Synthesis
Oral drug for the treatment of multiple sclerosis Fingolimod hydrochloride is the first oral drug for the treatment of multiple sclerosis. It is successfully developed by the pharmaceutical company Novartis, and it has been approved for marketing by the US Food and Drug Administration (FDA). The recommended dose is 0.5mg once a day for oral administration. 
Multiple sclerosis is a debilitating neurological disease that can cause the patient to lose a sense of balance, appear muscle spasms and other movement disorders. The disease has been treated with injectable drugs. This kind of medication brought great inconvenience to patients. 
Fingolimod is a sphingosine-l-phosphate (S1PR) receptor modulator. After phosphorylation, It is bound to s1P receptor that is on the surface of lymphocyte, which will change lymphocyte migration, and promote cells into the lymphatic tissue, and prevent lymphocytes from leaving the lymphoid tissue and get into the graft. Thereby, it will prevent these cells from infiltrating the central nervous system (CNS), which achieves the effect of immunosuppression. According to the drug's introduction, drugmaker Novartis said that this process of pharmacological effects is reversible. If medication is stopped, the level of lymphocytes in circulating system will return to normal. 
The above information is edited by the chemicalbook of Kui Ming.
Chemical Properties White Solid
Uses A derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibitin
Uses A derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. t is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
Uses Oral medicine for the treatment of multiple sclerosis
Uses FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolong s allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
Uses A cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties.
Definition ChEBI: The hydrochloride salt of 2-amino-2-[2-(4-octylphenyl) ethyl]-1,3-propanediol (fingolimod).
Fingolimod hydrochloride Preparation Products And Raw materials

 

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