Newblue CHEM Melatonine

Details:

Product Name: Melatonine
Synonyms: Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-;Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]-;Acetamide,N-[2-(5-methoxy-1H-indol-3-yl)ethyl];Melatonin(N-Acetyl-5-methoxytryptamine);3-N-Acetyl-5-methoxyl tryptamine;MELATONIN, 99.5+%;MELATONIN F&D VERSION FOR VETERINARY US;MELATONIN CRYSTALLINE
CAS: 73-31-4
MF: C13H16N2O2
MW: 232.28
EINECS: 200-797-7
Product Categories: Heterocyclic Series;Heterocycles series;Indoles;Tryptamines;Nutritional Supplements;Intermediates & Fine Chemicals;Pharmaceuticals;Melatonin receptor;Amines;Heterocycles;Melatonins;Alkaloid;Bioactive Small Molecules;Building Blocks;C13 to C27;Cell Biology;Cell Signaling and Neuroscience;Chemical Synthesis;Heterocyclic Building Blocks;M;Neurobiology;Neuroscience;Nutrition Research;Pharmacologicals;Phytochemicals by Chemical Classification;Vitamin series;Herb extract;Melatonex;inhibitor;Other APIs;Cosmetics;cosmetics materials;bulk drug material;Inhibitors
Mol File: 73-31-4.mol
Melatonine Structure
Melatonine Chemical Properties
Melting point  116.5-118 °C(lit.)
Fp  9℃
storage temp.  -15°C
solubility  Soluble in ethanol to at least 50mg/ml
form  Powder
color  white to off-white
Merck  14,5816
CAS DataBase Reference 73-31-4(CAS DataBase Reference)
NIST Chemistry Reference Melatonin(73-31-4)
Safety Information
Hazard Codes  T,F
Risk Statements  60-39/23/24/25-23/24/25-11
Safety Statements  24/25-99-53-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  2
RTECS  AC5955000
F  8-10-23
HS Code  29379000
Hazardous Substances Data 73-31-4(Hazardous Substances Data)

Melatonine Usage And Synthesis
description Melatonin is a hormone secreted by the pineal gland, and its chemical structure was 5-methoxy-N-acetyl tryptamine, the physiological function of inhibiting gonad, thyroid, adrenal gland, parathyroid gland and pituitary function, inhibit precocious puberty, reduce pituitary Melanotropin secretion; and has a central nervous system function, can improve the convulsion the threshold, cause drowsiness. When pinealectomy after the animal experiment showed hyperplasia of the glands, weight increase, especially sex and sexual organs of immature rats early, pituitary secretion of LH and FSH increased, increasing secretion of thyroid and adrenal cortex hormone melatonin. More reduced pituitary MSH and whiten the skin of this role. Effects on the central nervous system, in the human EEG showed slow rhythm, increased seizure threshold, sleepiness, but does not affect their behavior and personality, of temporal lobe epilepsy and Ba Jinsen disease can reduce the motor nerve Abnormal EEG changes.
Chemical properties White or almost white crystalline powder.
Uses 1. Melatonin can be used as medicine health care products, so as to enhance people’s immune function, preventing aging and back to youth. What’s more, it is also a kind of natural “sleeping pill”.
2. Melatonin is a kind of hormone secreted by pineal body of pituitary gland in the body. The amount of melatonin has something to do with light. The weaker the light is, the more the melatonin is, whereas the less. In addition, it is helpful to one’s sleep.
3. Biochemical research.
Physiological functions 1. The effect to brain: the melatonin obtained by brain mainly gathers in midbrain and hypothalamus and it adds the activity of brain pyridoxal kinase, thus promoting glutamic acid decarboxylation to γ-amino butyric acid, 5-hydroxytryptophane decarboxylation to 5-hydroxytryptamine, both of which can inhibit the increase of the neurotransmitter content and have an effect of adjustment and mitigation on central nervous system.
2. The effect to hypothalamus and pituitary: materials like polypeptide produced by pineal body still have thyrotropin-releasing hormone(TRH) and luteinizing hormone releasing hormone(LRH) which are same with what hypothalamus produces except AVT. After injection of melatonin, gonadotropin (GnH)(FSH,LH) and melanocyte stimulating hormone(MSH) are lowered while growth hormone increases. Cutting pineal gland will cause pituitary hypertrophy, increase pituitary secretion and lower prolactin(PRL) and antidiuretic hormone (ADH).
3. The relation to gonad: melatonin has an inhibitory effect on the reproductive system. Clinically, main cytoma of pineal body can lead to pubertal delay and when teratoma appears in pineal body, it may result in sexual precocity because main cells are excluded. Ambient light and sympathetic nerve can affect the function of the reproductive system by inhibiting the synthesis and release of melatonin in pineal gland.
4. The relation to thyroid: by injecting melatonin, thyroid secretion will decrease. This may be caused through the inhibition of the hypothalamus release and Thyroid Stimulating Hormone (TSH) secretion of pituitary, hence holding back the function of thyroid.
5. The relation to adrenal cortex: melatonin has a strong inhibitory effect on adrenal cortex. If we inject pineal body extracts to healthy people, we will find that their aldosterone secretion and 17-ketosteroid output will decrease.
6. The relation to pancreatic island: melatonin can lower blood glucose and increase sugar tolerance. In conclusion, pineal gland can assist pituitary to jointly adjust endocrine function and play an vital role in keeping relatively constant in body environment and controlling some endocrine function, especially for gonad.