375815-87-5 Varenicline tartrate 98%
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Varenicline tartrate Basic information |
Product Name: | Varenicline tartrate |
Synonyms: | VARENICLINE TARTRATE;Varenicline tartrate for research;7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine (2R,3R)-2,3- dihydroxybutanedioate;Champix;CP 526555-18;6,10-Methano-6H-pyrazino(2,3-H)(3)benzazepine, 7,8,9,10-tetrahydro-, (2R,3R)-2,3-dihydroxybutanedioate (1:1);Unii-82269asb48;,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro- |
CAS: | 375815-87-5 |
MF: | C17H19N3O6 |
MW: | 361.34926 |
EINECS: | 200-659-6 |
Product Categories: | Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;APIs;Pfizer compounds;Chantix, Champix;Inhibitors |
Mol File: | 375815-87-5.mol |
Varenicline tartrate Chemical Properties |
Melting point | 206-208°C |
storage temp. | Desiccate at RT |
solubility | DMSO: >5mg/mL |
color | white to beige |
Safety Information |
Hazard Codes | Xn,N,T,F |
Risk Statements | 22-50-39/23/24/25-23/24/25-11 |
Safety Statements | 22-57-45-36/37-16-7 |
RIDADR | UN 3077 9 / PGIII |
Varenicline tartrate Usage And Synthesis |
Chemical Properties | Tan Solid |
Uses | Nicotinic a4 acetylcholine receptor partial agonist. Aid in smoking cessation. |
Uses | Nicotinic α4β2 acetylcholine receptor partial agonist. Aid in smoking cessation. |
Uses | Varenicline is a prescription medication used to treat smoking addiction. Varenicline is a nicotinic receptor partial agonist. In this respect, it is similar to cytisine and different from the nicotinic antagonist, bupropion, and nicotine replacement ther |
Definition | ChEBI: A tartrate salt obtained by reaction of varenicline with one equivalent of (R,R)-tartaric acid. A partial agonist for nicotinic cholinergic receptors, it is used as an aid to giving up smoking. |
Biological Activity | Orally active, subtype-selective partial agonist at α 4 β 2 nicotinic receptors (K i values are 0.06, 240, 322 and 3540 nM for α 4 β 2, α 3 β 4, α 7, α 1 β γ δ receptors respectively). Reduces nicotine-evoked dopamine release in vitro and decreases nicotine self-administration in vivo . |
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