375815-87-5 Varenic...

375815-87-5 Varenicline tartrate

375815-87-5 Varenicline tartrate

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1 Kilogram

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  • Min.Order :1 Kilogram
  • Purity: 98.0%Min
  • Payment Terms : L/C,T/T,,MoneyGram,Other

Keywords

375815-87-5 Varenicline tartrate 98%

Quick Details

  • Appearance:Powder
  • Application:Pharma intermediates
  • PackAge:1KG -200KG Drum with pallet
  • ProductionCapacity:30|Metric Ton|Month
  • Storage:Desiccate at RT
  • Transportation:by sea or by air or by courier

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Details:

 
Varenicline tartrate Basic information
Product Name: Varenicline tartrate
Synonyms: VARENICLINE TARTRATE;Varenicline tartrate for research;7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine (2R,3R)-2,3- dihydroxybutanedioate;Champix;CP 526555-18;6,10-Methano-6H-pyrazino(2,3-H)(3)benzazepine, 7,8,9,10-tetrahydro-, (2R,3R)-2,3-dihydroxybutanedioate (1:1);Unii-82269asb48;,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-
CAS: 375815-87-5
MF: C17H19N3O6
MW: 361.34926
EINECS: 200-659-6
Product Categories: Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;APIs;Pfizer compounds;Chantix, Champix;Inhibitors
Mol File: 375815-87-5.mol
Varenicline tartrate Structure
 
Varenicline tartrate Chemical Properties
Melting point  206-208°C
storage temp.  Desiccate at RT
solubility  DMSO: >5mg/mL
color  white to beige
 
Safety Information
Hazard Codes  Xn,N,T,F
Risk Statements  22-50-39/23/24/25-23/24/25-11
Safety Statements  22-57-45-36/37-16-7
RIDADR  UN 3077 9 / PGIII
MSDS Information
 
 
Varenicline tartrate Usage And Synthesis
Chemical Properties Tan Solid
Uses Nicotinic a4 acetylcholine receptor partial agonist. Aid in smoking cessation.
Uses Nicotinic α4β2 acetylcholine receptor partial agonist. Aid in smoking cessation.
Uses Varenicline is a prescription medication used to treat smoking addiction. Varenicline is a nicotinic receptor partial agonist. In this respect, it is similar to cytisine and different from the nicotinic antagonist, bupropion, and nicotine replacement ther
Definition ChEBI: A tartrate salt obtained by reaction of varenicline with one equivalent of (R,R)-tartaric acid. A partial agonist for nicotinic cholinergic receptors, it is used as an aid to giving up smoking.
Biological Activity Orally active, subtype-selective partial agonist at α 4 β 2 nicotinic receptors (K i values are 0.06, 240, 322 and 3540 nM for α 4 β 2, α 3 β 4, α 7, α 1 β γ δ receptors respectively). Reduces nicotine-evoked dopamine release in vitro and decreases nicotine self-administration in vivo .

 

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