TIANFUCHEM--206361-99-1--High purity 6-Methylpyridine-3-carboxylic acid factory price

Darunavir

English Synonyms: [(1S, 2R) -3 - [(4-Aminophenyl) sulfonyl] carabamic Acid (3R, 3aS, 6aR ) -Hexahydrofuro [2,3-b] -furan-3-yl Ester; Darunavir; TMC-114; UIC-94017; [2-methylpropyl] (3R, 3aS, 6aR) -Hexahydrofuro [2,3-β] -furan-3-yl Ester; [(3R, 3aS, 6aR ) -2,3,3a, 4,5,6a-Hexahydrofuro [5,4-b] furan-3-yl] N - [(2S, 3R) -4 - [(4-aminophenyl) sulfonyl- methylpropyl) amino] -3-hydroxy-1-phenylbutan-2-yl] carbamate; D03656; Darunavir (usan / inn)

CAS number: 206361-99-1

Molecular formula: C27H37N3O7S

Molecular weight: 547.66

EINECS number:

Related Categories: Antiviral Agents; Antivirals; Intermediates & Fine Chemicals; Pharmaceuticals; Aromatics; Heterocycles; Inhibitors; Pharmaceutical Intermediates; Peptides; Antibiotics; Microbiology; Microbiology;

Mol file: 206361-99-1.mol

Darinavir

Darinavir Nature

Melting point 74-760C

Storage conditions -20 ° C Freezer

Darunaviruse and method of synthesis

AIDS treatment drug darunavir is a new non-peptide anti-retroviral protease inhibitor for AIDS treatment was first developed by Johnson & Johnson's Icelandic branch of Tibotec, is currently the six protease inhibitors (saquinavir , Ritonavir, indinavir, naphinavir, anrenavir, and ABT378 / r), by blocking the release of new, mature virions from the surface of infected host cells The formation of the process, inhibit the protease and the virus play a role. When long-term use of this product, usually can reduce blood HIV vector, increase the count of CD4 cells, reduce the chance of AIDS, improve quality of life and prolong life. For adults who have not been infected with HIV but who have taken an active antiretroviral drug, the drug must be used in combination with low doses of ritonavir or other antiretroviral agents to improve the efficacy. In vitro anti-viral activity against lymphocytes in acute and chronic infected lymphocytes and in peripheral blood can be evaluated with IC50 of 0.012-0.08 mmol / L for acutely infected cells and 0.41 mmol / L for chronic infected cells . Oral medication, the recommended dose of a 1200mg, 1 2 times, mild to moderate liver dysfunction in patients with renal dysfunction should be reduced. The main adverse reactions of darunavir gastrointestinal reaction, flushing, itching and perioral numbness, depression, emotional disorders, such as taste disorders. This product is not recommended for patients with moderate to severe liver dysfunction. Because of this component