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Details:
Product Name: Suplatast tosilate
Synonyms: (2-(4-(3-ethoxy-2-hydroxypropoxy)phenylcarbamoyl)ethyl)dimethylsulfonium p-toluenesulfonate;SUPLATAST TOSILATE;Suplatast tosylate;Suplatast;2-[4-(2-Hydroxy-3-ethoxypropoxy)phenylcarbamoyl]ethyldimethylsulfonium·4-methylbenzenesulfonate;IPD-1151T;S,S-Dimethyl-3-oxo-3-[4-(2-hydroxy-3-ethoxypropoxy)anilino]propane-1-sulfonium·4-methylbenzenesulfonate;[2-[[[4-(2-Hydroxy-3-ethoxypropoxy)phenyl]amino]carbonyl]ethyl]dimethylsulfonium
CAS: 94055-76-2
MF: C23H33NO7S2
MW: 499.64062
EINECS:
Product Categories: API;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;IPD 1151T
Mol File: 94055-76-2.mol
Suplatast tosilate Structure
Suplatast tosilate Chemical Properties
Melting point 84-87°C
storage temp. Store at RT
solubility DMSO: >20mg/mL
color white to off-white
Merck 14,9003
CAS DataBase Reference 94055-76-2(CAS DataBase Reference)
Safety Information
RTECS WR7906000
MSDS Information
Suplatast tosilate Usage And Synthesis
Uses Suplatast Tosylate is an antiallergic drug. Suplatast Tosylate inhibits antigen-induced histamine release from mast cells as well as IgE antibody formation. Suplatast Tosylate suppresses interleukin (IL)-4 release from T cells, however in human peripheral basophils, Suplatast Tosylate inhibited the antigen-induced release of IL-13 but not IL-4.
Uses Suplatast Tosilate is a novel capsular anti-asthmatic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.
Biological Activity Th2 cytokine inhibitor that attenuates IL-2, IL-5 and IL-13 production and has no effect on IFN- γ production. Acts as an immunoregulator that suppresses IgE production, eosinophil infiltration and histamine release. Exhibits antiasthmatic, anti-inflammatory and antifibrotic activity in vivo and is orally active.