C26H27N5O2.ClH VILAZODONE 163521-12-8

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1 Metric Ton	Negotiable

1 Metric Ton

Negotiable

Min.Order :1 Metric Ton
Purity: 99.5%
Payment Terms : L/C,T/T,

Keywords

VILAZODONE 163521-12-8 C26H27N5O2.ClH

Quick Details

Appearance:Powder
Application:163521-12-8
PackAge:Aluminium Foil Bag and Paper Drum
ProductionCapacity:100|Metric Ton|Day
Storage:1MT
Transportation:By Sea/Air/DHL

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Details:

VILAZODONE Basic information

Description References

Product Name:	VILAZODONE
Synonyms:	5-(4-(4-(5-Cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide;2-BenzofurancarboxaMide,5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-;Vilazodonei;Vilazodone 5-[4-[4-(5-Cyanoindol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxamide;5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide;Vilazodone, >=98%;Vilozodone;VILAZODONE
CAS:	163521-12-8
MF:	C26H27N5O2.ClH
MW:	477.993
EINECS:
Product Categories:	Other APIs;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	163521-12-8.mol

VILAZODONE Chemical Properties

Melting point	203-205°C
storage temp.	Refrigerator

Safety Information

MSDS Information

VILAZODONE Usage And Synthesis

Description	Vilazodone is a kind of serotonergic antidepressant developed by Merck KGaA Company. It is a novel compound with high affinity and selectivity for the 5-hydroxytrptamine (5-HT) transporter and 5-HT (1A) receptors. It is indicated for the treatment of major depressive disorder (MDD). It is can be used as an alternative drugs for other kind of antidepressant classes drugs that can’t be tolerated by patients. As a selective serotonin reuptake inhibitor, vilazodone can prevent the serotonin from re-entering into cell bodies, therefore making it remain longer inside the synapse. Moreover, it has a high selectivity for the serotonin-1A receptor, taking effect as a partial agonist that can simulate the production of serotonin. These effects result in increased serotonin in the synaptic cleft. This effect is related to the antidepressant effect of vilazodone in vivo.
References	# # #
Chemical Properties	Light Yellow Solid
Uses	Labelled analogue of Vilazodone
Uses	An inhibitor of ST and activator of SR-1A
Uses	It is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.
Definition	ChEBI: A 1-benzofuran that is 5-(piperazin-1-yl}-1-benzofuran-2-carboxamide having a (5-cyanoindol-3-yl)butyl group attached at position N-4 on the piperazine ring. Used for the treatment of major depressive disorder.

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