Fludarabine 21679-14-1 TIANFU CHEM Fludarabine
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Fludarabine Basic information
Product Name: Fludarabine
Synonyms: 2-Fluoroadeninearabinoside;9-beta-d-arabinofuranosyl-2-fluoro-9h-purin-6-amin;9-beta-d-arabinofuranosyl-2-fluoro-adenin;f-ara-a;6-AMINO-9 BETA-D-ARABINOFURANOSYLFLUOROPURINE;9-bata-d-arabinofuranosyl-2-fluoroadenine;9-BETA-D-ARABINOFURANOSYL-2-FLUORO-9H-PURIN-6-AMINE;9-BETA-D-ARABINOFURANOSYL-2-FLUOROADENINE
CAS: 21679-14-1
MF: C10H12FN5O4
MW: 285.23
EINECS: 244-525-5
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;API;F-ara-A, NSC 118218;Anti-cancer&immunity;Inhibitors
Mol File: 21679-14-1.mol
Fludarabine Structure
Fludarabine Chemical Properties
Melting point 265-268°C
alpha D25 +17 ±2.5° (c = 0.1 in ethanol)
storage temp. 2-8°C
solubility DMF: 20 mg/mL, clear, faintly yellow
form Powder
color White to Pale Yellow
Water Solubility Soluble in DMF, DMSO, methanol or ethanol. Sparingly soluble in water
Merck 13,4152
CAS DataBase Reference 21679-14-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 23/24/25-36/37/38-39/23/24/25-39-22
Safety Statements 26-36/37-45-36
WGK Germany 3
RTECS AU6207000
F 10
Hazardous Substances Data 21679-14-1(Hazardous Substances Data)
Fludarabine Usage And Synthesis
Chemical Properties White Solid
Uses Used as an antineoplastic
Uses A STAT-1 activation inhibitor and a DNA synthesis inhibitor.
Uses phosphate as antineoplastic;inhibits DNA synthesis by interfering with ribonucleotide reductase and DNA polymerase
Uses Irreversible muscarinic agonist
Uses DNA synthesis and methylation inhibitor;A cell permeable agent that interferes with DNA synthesis and repair; also inhibits RNA transcription
Biological Activity Purine analog that inhibits DNA synthesis. Exhibits antiproliferative activity (IC 50 = 1.54 μ M in RPMI cells) and triggers apoptosis through increasing Bax and decreasing Bid, XIAP and survivin expression. Displays anticancer activity against hematological malignancies in vivo .
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