Muscle Enhancement Steroids 4-Androstenedione Anabolic Steroids Pharmacy

Details:

Quick Details:

 

• 4-Androstenedione
• Alias: 4 - androstenedione; 4 - male (steroid)-ene -3,17 - dione;
• Purity : 99%min
• CAS Registry Number: 63-05-8
• Einecs No: 200-554-5
• Molecular formula:C19H26O2
• Molecular weight:286.4085
• Grade : Pharmaceutical Grade
• Storage: Shading, confined preservation
• Usage : pharmaceutical material, etc 

 
 

Description:

 

 

1 .  Androstenedione is a steroid hormone which is used for pharmaceutical, and is the common precursor

 

of male and female sex hormones. Some androstenedione is also secreted into the plasma, and may be

 

converted in peripheral tissues to testosterone and estrogens.
 

 

 

2 .  Androstenedione can be synthesized in one of two ways. The primary pathway involves conversion of

 

17-hydroxypregnenolone to dehydroepiandrosterone by way of 17,20-lyase, with subsequent conversion

 

ofdehydroepiandrosterone to androstenedione via the enzyme 3-hydroxysteroid dehydrogenase. The

 

secondary pathway involves conversion of 17-hydroxyprogesterone, most often a precursor to cortisol, to

 

androstenedione directly by way of 17,20-lyase. Thus, 17,20-lyase is required for the synthesis of

 

androstenedione, whether immediately or one step removed.
 

 

 

3 . The production of adrenal androstenedione is governed by ACTH, whereas production of gonadal

 

androstenedione is under control by gonadotropins. In premenopausal women, the adrenal glands and

 

ovaries each produce about half of the total androstenedione(about 3 mg/day). After menopause,

 

androstenedione production is about halved, due primarily to the reduction of the steroid secreted by the

 

ovary. Nevertheless, androstenedione is the principal steroid produced by the postmenopausal ovary.

 

 

Specifications :

 

Test Items	Specification	Test Results
Appearance	White crystalline powder	Comply
Assay	≥99%(HPLC) (titration)	99.33%
Melting point	170.0-174.0ºC	171.6-173.5ºC
Loss on drying	≤0.5%	0.01%
Specific rotation	+193°~+202°	+195°

 

 

 

 

Applications:  
 

 

1 .  Androstenedione is the common precursor of male and female sex hormones. Some androstenedione

 

is also secreted into the plasma, and may be converted in peripheral tissues to testosterone and

 

estrogens.
 

 

2 .  Androstenedione can be synthesized in one of two ways. The primary pathway involves conversion of

 

17-hydroxypregnenolone to dehydroepiandrosterone by way of 17,20-lyase, with subsequent conversion

 

ofdehydroepiandrosterone to androstenedione via the enzyme 3-hydroxysteroid dehydrogenase. The

 

secondary pathway involves conversion of 17-hydroxyprogesterone, most often a precursor to cortisol, to

 

androstenedione directly by way of 17,20-lyase. Thus, 17,20-lyase is required for the synthesis of

 

androstenedione, whether immediately or one step removed.
 

 

3 . The production of adrenal androstenedione is governed by ACTH, whereas production of gonadal

 

androstenedione is under control by gonadotropins. In premenopausal women, the adrenal glands and

 

ovaries each produce about half of the total androstenedione(about 3 mg/day). After menopause,

 

androstenedione production is about halved, due primarily to the reduction of the steroid secreted by the

 

ovary. Nevertheless, androstenedione is the principal steroid produced by the postmenopausal ovary.