Items of analysis
|
Specification
|
Results
|
Appearance
|
white or almost white, crystalline powder
|
Almost white crystalline powder
|
Solubility
|
Practically insoluble in water ,sparingly soluble in anhydrous ethanol, very slightly soluble in methylene chloride.
|
Conforms
|
Identification (B,C)
|
Complies with the Standard
|
Complies
|
Specific optical Rotation
|
+118°~+126°
|
+123.0°
|
impurity that ≥0.5%
|
Not more than one
|
Complies
|
total impurities
|
Not more than 2.0%
|
0.90%
|
Loss on drying
|
Not more than 0.5%
|
0.06%
|
Assay(UV, basis on drying)
|
97.0%~103.0%
|
99.7%
|
Particle Size
|
100.0%<100um
|
Complies
|
Methanol
|
Not more than 3000ppm
|
Complies
|
Ethyl acetate
|
Not more than 5000ppm
|
Complies
|
Acetone
|
Not more than 5000ppm
|
Complies
|
N,N-Dimethylformamide
|
≤880ppm
|
ND
|
DMF
|
Not more than 880ppm
|
Complies
|
Dichloromethane
|
Not more than 600ppm
|
Complies
|
Chloroform
|
Not more than 60ppm
|
Complies
|
What is Betamethasone
Betamethasone is a steroid medication. It is used for a number of diseases including rheumatic disorders such as rheumatoid arthritis and systemic lupus erythematosus, skin diseases such as dermatitis and psoriasis, allergic conditions such as asthma and angioedema, preterm labor to speed the development of the baby's lungs, Crohn's disease, cancers such as leukemia, and along with fludrocortisone for adrenocortical insufficiency, among others. It can be taken by mouth, injected into a muscle, or applied as a cream.When given by injection, anti-inflammatory effects begin in around two hours and last for seven days.
Betamethasone benefits:
Betamethasone is used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions.
Treating certain conditions associated with decreased adrenal gland function. It is used to treat severe inflammation caused by certain conditions, including severe asthma, severe allergies, rheumatoid arthritis, ulcerative colitis, certain blood disorders, lupus, multiple sclerosis, and certain eye and skin conditions. It may be used for certain types of cancer (eg, leukemia). It may also be used for other conditions as determined by your doctor.
How to use Betamethasone topical
(1)Betamethasone comes in ointment, cream, lotion, and aerosol (spray) in various strengths for use on the skin. It is usually applied one to four times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use betamethasone exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor. Do not apply it to other areas of your body or wrap or bandage the treated area unless directed to do so by your doctor.
(2)Wash or soak the affected area thoroughly before applying the medicine, unless it irritates your skin. Then apply the ointment or cream sparingly in a thin film and rub it in gently.
(3)To use the lotion on your scalp, part your hair, apply a small amount of the medicine on the affected area, and rub it in gently. Protect the area from washing and rubbing until the lotion dries. You may wash your hair as usual but not right after applying the medicine.
(4)To apply an aerosol, shake well and spray on the affected area holding the container about 3 to 6 inches away. Spray for about 2 seconds to cover an area the size of your hand. Take care not to inhale the vapors. If you are spraying near your face, cover your eyes.