17β-estradiol Pharmaceutical Intermediate Estradiol Estrogen Steroids CAS 50-28-2

Quick Details:

 

• Estradiol 
• Alias:17β-estradiol
• Purity : 99%min
• CAS Registry Number: 50-28-2
• Einecs No: 200-023-8
• Molecular formula: C18H24O2
• Molecular weight:272.39
• Grade : Pharmaceutical Grade
• Storage: Shading, confined preservation
• Usage : pharmaceutical material, etc 

 
 

 

Description:

 

 

1. This product is white or milky white odorless crystalline powder; In dioxane, dissolved in acetone,

 

slightly soluble in ethanol, insoluble in water.Estradiol is a sex hormone that is present in both males and

 

females, and is the most important form of estrogen in humans. In women, it plays a key role in the

 

development and functioning of the reproductive system, as well as in the growth of certain bones. It also

 

governs the distribution of body fat in women and is the main hormone responsible for the fact that women

 

are shorter than men, on average. Both the ovaries and the adrenal glands produce it.

 

 

2. The menstrual cycle in women involves predictable variations in the levels of several hormones, with

 

estradiol being one of them. It is involved in the ovulation process and prepares the inner lining of the

 

uterus for implantation, should the egg be fertilized. Certain tests done on baboons and other primates

 

have indicated that his hormone also plays a continual role in maintaining a pregnancy, helping it to last

 

for the full gestation period.

 

 

3.  As a sex hormone, it also triggers many of the developments of the reproductive system that begin in

 

puberty. It is present throughout the reproductive years, and declines during and after menopause. This

 

decline is precisely what causes many of the symptoms of menopause, such as hot flashes and night

 

sweats, vaginal dryness, and the loss of bone mass that may lead to osteoporosis.

 

 

4.  Estradiol for functional uterine bleeding, primary amenorrhea, menopausal syndrome, prostate cancer.

 

Can promote and regulate the female sexual organs and sexual characteristics of the normal

 

development. Can promote the development of mammary duct proliferation, but in a larger dose, can

 

inhibit the release of anterior pituitary prolactin, while reducing milk secretion. Can also be used to return

 

milk. But may have nausea, vomiting and endometrial hyperplasia and bleeding. Liver and kidney

 

dysfunction with caution. Avoid for the breast, vulva and vaginal mucosa.

 

 

Specifications :

 

 

Product name	Estradiol
Appearance	White crystalline powder
Characteristics	White or creamy white, crystalline powder	conform
Melting point	173 ~ 179°C	178~ 179°C
Specific rotation	+76°~+83°	+78.5°
Water	≤3.5%	pass
Assay	97 .0~ 103.0%	99.07%
Loss on drying	≤0.5%	0.21%
Related substances	total impurities ≤1.0%	Pass
	any individual impurity ≤0.5%	Pass
Residual solvents	ethanol ≤0.5%	Pass

 

 

 

Applications:  
 

 

 

1. This medication is a female hormone (estrogen). It is used by women to help reduce symptoms of

 

menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less

 

estrogen. If you are using this medication to treat symptoms only in and around the vagina, products

 

applied directly inside the vagina should be considered before medications that are taken by mouth,

 

absorbed through the skin, or injected. This medication may also be used by women who are not able to

 

produce enough estrogen (for example, due to hypogonadism, primary ovarian failure).

 

 

2.  As a sex hormone, E2 has several different functions in women’s fertility. First, it helps to build and

 

protect the lining of the fallopian tubes, vagina, and uterus. This role is critical to get the embryo to attach

 

to the uterine wall. Many women who experience fertility problems have low levels of estradiol. Second, E2

 

maintains the oocytes, or egg cells, in the ovary. Healthy oocytes lead to healthy embryos. Only the best

 

oocyte is selected at each ovulation period to be released and possibly

 

 

3.  As a tissue builder, E2 seems to help protect women from heart disease by raising the levels of HDL,

 

the “good” cholesterol in the body. When hormone levels drop in postmenopausal women, their risk of

 

heart disease increases. E2 also helps protect bone density in both men and women by participating in a

 

messaging system that suppresses an overly rapid growth of immune cells in the bone. If more immune

 

cells are allowed to grow, they can block calcium absorption in the bone. This is why men with lower levels

 

of this hormone in their system have been found to be more susceptible to hip fractures.