Propitocaine Hydrochloride Pain Killer CAS No.: 1786-81-8

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Propitocaine Hydrochloride Pain Killer CAS No.: 1786-81-8



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Propitocaine hydrochloride
Product name: Propitocaine hydrochloride
Synonyms: Prilocaine hydrochloride;2-(Propylamino)-o-propionotoluidide hydrochloride; alpha-propylamino-2'-methylpropionanilide hydrochloride; Citanest; N-(2-Methylphenyl)-2-(propylamino)-propanamide hydrochloride; N-(a-propylaminopropionyl)-o-toluidine hydrochloride; Prilocaine hydrochloride; Xylonest; ; N-(2-methylphenyl)-N~2~-propylalaninamide hydrochloride (1:1); Propitocaine HCL
CAS No.: 1786-81-8
Assay: 98%
Packing: 25kg/drum
M.F.: C13H21ClN2O
M.W.: 256.7716
Appearance: White crystalline powder



Description:



1. Prilocaine is a local anesthetic of the amino amide type. Prilocaine is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/pril ocaine or EMLA), for treatment of conditions like paresthesia.
 
2. Local anesthetic is a substance that causes loss of sensation only to the area to which it is applied without affecting consciousness. Most local anesthetics structures have amino-ester or an amino-amide group which are linked to hydrophilic (secondary or tertiary amine) and to hydrophobic group (aromatics) on the other sid.
 
3. The ester can be hydrolysed in plasma by the enzyme pseudocholinesterase into para-aminobenzoic acid. Amide is stable for longer acting and more systemic distribution. Ester types include Procaine (Novocain), Chloroprocaine (Nesacaine), Tetracaine (Pontocaine), Benzocaine, Tetracaine. Amide types include Lidocaine (Xylocaine),
 
4. Mepivacaine(Carbocaine), Prilocaine (Citanest), Bupivacaine (Marcaine), Etidocaine (Duranest).


 Applications:


Prilocaine is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils L fgren.
In its injectable form (trade name Citanest), it is often used in dentistry. It is also often combined with
lidocaine as a preparation for dermal anesthesia, for treatment of conditions like paresthesia. As it has low
cardiac toxicity, it is commonly used for intravenous regional anaesthesia (IVRA). In some patients, a
metabolite of prilocaine may cause the unusual side effect of methemoglobinemia, which may be treated
with methylene blue. Maximum dosage for dental use: 8.0 mg/kg (2.7 mg/lb), with a maximum dose of 500
mg.

Eutectic Mixture of Local Anesthetics (EMLA) containing 5% lidocaine and prilocaine in a cream was found
to give effective topical analgesia in normal and diseased skin, making it useful for superficial surgery and
various other clinical procedures. To be effective, an adequate amount must be applied under occlusion
and at the right time before the intervention.

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Propitocaine Hydrochloride Pain Killer CAS No.: 1786-81-8