Anesthetic Drugs Tetracaine Pharmaceutical Intermediate CAS 94-24-6

 

 

 

99% Pharmaceutical Raw Materials white Tetracaine Pain Killer CAS 94-24-6

 

 

Quick Details:

 

• Product Name Tetracaine
  Synonym Anetain, Amethocaine, Pontocaine,Ametop,Dicaine
• CAS 94-24-6
• MF C15H24N2O2
• MW 264.36
• EINECS 202-316-6
• Assay 99%
• Quality Standards Enterprise Standard/Pharma Grade
• Appearance White powder
• Package 25kg/Drum

 

 

Product Description:

 

 

 Tetracaine (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

 

 1) Tetracaine is a local anesthetic (numbing medicine). It works by blocking nerve signals in your body.
 

 2) Tetracaine topical may also be used for purposes not listed in this medication guide.
 

 3) Tetracaine topical (for the skin) is used to numb different parts of the body before a medical test or procedure.
 

 4) In the manufacture of pharmaceutical preparation for external use, to relieve the pain of drugs or medication lesions pain.

 

Specifications:

 

 

Test Items	Specification	Test Results
Appearance	Fine, white, crystalline, odorless powder	confirm
Identification	ABC in Pass	confirm
Solubility	Very soluble in water, soluble in Alcohol; insoluble in Ether and Benzene	confirm
USP Reference standards	USP Tetracaine Hydrochloride RS. USP Endotoxin RS.	confirm
Melting point	145~150 degree	146.0~147.5 degree
Chromatographic purity	In Pass	confirm
Related substance	Not more than the reference solution 0.05%	confirm
Heavy metals	≤10ppm	confirm
PH	4.5-6.5	5.8
Residue on ignition	≤0.10%	0.05%
Loss on Drying	≤ 0.5%	0.19%
Assay	98.0 -101.0%	100.1%
Conclusion	Confirms USP 32

 

 

Applications:

 

 

 (1) In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

 (2) Tetracaine is the T in Tac, a mixture of 5 to 12 per cent tetracaine, 5M(per myriad), a half per mille (0.5‰), or .05 per cent (1 part in 2000) , and 4 or 10 per cent hydrochloride used in ear, nose & throat surgery and in the emergemcy department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.

 (3) Tetracaine is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.