MONOCROTALINE

MONOCROTALINE

MONOCROTALINE

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1 Gram

FOB Price: USD 1.0000

  • Min.Order :1 Gram
  • Purity: 99% min
  • Payment Terms : L/C,T/T,

Keywords

MONOCROTALINE high purity MONOCROTALINE factory supply MONOCROTALINE

Quick Details

  • Appearance:White to light tan powder
  • Application:Pharmaceutical intermediates
  • PackAge:as you requested
  • ProductionCapacity:10|Kilogram|Day
  • Storage:Room temperature
  • Transportation:by courier

Superiority:

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below:
 
1.Noble Metal Catalysts (Pt.Pd...)
2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)
3.OLED intermediates (Fluorene,Carbazole,Boric acid...)
4.Customs Synthesis
 
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Anyway ,if you need any chemicals from China ,Henan Tianfu can help you

Details:

Description References
Product Name: MONOCROTALINE
Synonyms: MONOCROTALIN;MONOCROTALINE;CROTALIN;CROTALINE;(13-alpha,14-alpha)-14,19-dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dio;(13-alpha,14-alpha)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione;(2,3,4-gh)pyrrolizine-2,6(3h)-dione,(4,5,8,10,12,13,13a,13b-octahydro-4,5-dihy;(2,3,4-gh)pyrrolizine-2,6(3H)-dione,(4,5,8,10,12,13,13a,13b-octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-(1,6)dioxacycloundecino-
CAS: 315-22-0
MF: C16H23NO6
MW: 325.36
EINECS: 2017-001-1
Product Categories: Miscellaneous Natural Products;Amines;Heterocycles;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
Mol File: 315-22-0.mol
MONOCROTALINE Structure
 
MONOCROTALINE Chemical Properties
Melting point  204 °C (dec.)(lit.)
alpha  -54.8o (C=5 IN CHLOROFORM)
storage temp.  2-8°C
Merck  13,6274
 
Safety Information
Hazard Codes  T
Risk Statements  25-40-35
Safety Statements  36/37/39-45
RIDADR  UN 1544 6.1/PG 3
WGK Germany  3
RTECS  QB3140000
HazardClass  6.1(b)
PackingGroup  III
MSDS Information
Provider Language
SigmaAldrich English
ACROS English
 
MONOCROTALINE Usage And Synthesis
Description Monocrotaline (MCT) is a toxic 11-membered macrocyclic pyrrolizidine alkaloid (PA) derived from the seeds of the Crotalaria spectabilis plant. It poisons livestock and humans through the ingestion of contaminated grains and other foods. Pyrrolizidine alkaloid is activated by cytochrome P450 to the reactive pyrrole metabolite dehydromonocrotaline (MCTP) in the liver. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature.
Monocrotaline is produced for research use. It is used in rat model to investigate human pulmonary hypertension as it offers technical simplicity, reproducibility, and low cost compared with other models of pulmonary hypertension.
References [1] Jose G. Gomez-Arroyo, Laszlo Farkas, Aysar A. Alhussaini, Daniela Farkas, Donatas Kraskauskas, Norbert F. Voelkel, Harm J. Bogaard (2012) The monocrotaline model of pulmonary hypertension in perspective, Am J Physio Lung Cell Mol Phyisol, 302, L363-L369
[2] #
Chemical Properties White to light tan powder
Uses A toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats.
Uses antineoplastic, insect sterilant

 

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