ArtemetherishighlyeffectiveagainstthebloodschizontsofbothmalarialparasitesP.falciparumandP.vivax.Itisappliedincombinationwithlumefantrineincli
Artemether is highly effective against the blood schizonts of both malarial parasites P. falciparum and P. vivax. It is applied in combination with lumefantrine in clinical treatments of malaria. World Health Organization guidelines for the treatment of uncomplicated falciparum malaria recommend the use of this artemisinin-based combination therapy, and approved by Swissmedic in December 2008 and recently approved by the United States Food and Drug Administration.
Artemether has been assigned to category C by the FDA on the basis of animal data which shows an association with fetal-loss and deformity. However, clinical data appears to show that artemether is safe in pregnancy.
Anthelmintic
During early 1980s Chinese scientists, by serendipity, discovered that artemether was not only an antimalarial agent, but also effective against the blood flukes. Eventually, laboratory experiments have confirmed the broad spectrum of activity against different trematodes, including all human schistosomes, Clonorchis sinensis, Fasciola hepatica and Opisthorchis viverrini.[8]
Anticancer
Artemether has been shown to have significant anticancer and antitumor activities. It is demonstrated that artemether caused strong inhibitory effects on brain glioma growth and angiogenesis in rats.[11] other uses
Some medications have more than one effect on the body. In addition to anti malarial action Artemether has analgesic–antipyretic effects on the body by relieving pain and reducing fever.
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