Active Pharmaceutical Ingredients Tianeptine sodium CAS 30123-17-2 for Anti-Depression

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Active Pharmaceutical Ingredients Tianeptine sodium  CAS 30123-17-2 for Anti-Depression

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Product Name:Tianeptine sodium salt
Synonyms:
TIANEPTINE SODIUM;TIANEPTINE SODIUM SALT;sodium 7-((3-chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoate s,s-dioxide;7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic Acid S,S-Dioxide Sodium Salt;S-1574;Stablon;7-[(3-chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine-11-yl)amino]heptanoic acid s,s dioxide sodium salt;Sodium 7-((3-chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoate S,S-dioxide;
CAS: 30123-17-2;
MF: C21H24ClN2NaO4S ;
MW: 458.93;
EINECS: 250-059-3

Introduction:

Everyone experiences variations in mood - transitory blues, disappointments, the normal grief that accompanies the loss of someone you love. But a severe or prolonged depression that interferes with the ability to function, feel pleasure, or maintain interest is not a mere case of the blues. It is an illness. Researchers have demonstrated that it results from biochemical imbalances in the brain.
 
In depression faith in deliverance, in ultimate restoration, is absent. The pain is unrelenting, and what makes the condition intolerable is the foreknowledge that no remedy will come not in a day, an hour, a month, or a minute. It is hopelessness even more than pain that crushes the soul. -William Styron, 1990

Depression is one of the most common mental disorders affecting approximately 340 million people in the world. No one is immune from depression - it occurs in people of all social classes, all countries and all cultural settings.

Medical Application of Active Pharmaceutical Ingredients Tianeptine sodium salt:

1.Its main function is to facilitate serotonin reuptake. According to a study done in rats, changes were noticed when tianeptine was administered like serotonin levels increased in the hippocampus area which doesn't usually happen to other tricyclic anti-depressant drugs.

2. Furthermore, it is also considered to be a nootropic agent for it has neuroprotective effects. Based on the recent studies, tianeptine prevents and reverse stress-induced neural damage leading to the survival of neurons and synaptic plasticity promotion. Therefore, tianeptine helps one to handle a stressful situation. Also, it has the ability to improve concentration therefore helping those with very short attention spans and poor focus.

3.Also, it lessens stress-induced apoptosis or self-cell destruction, specifically in the hippocampus. In the hippocampus, tianeptine has the ability to avoid overstimulation of glutamate (AMPA and kainite type) receptors that controls the entry of Ca2+ inthe nerve cells for too much Ca2+ means toxic.

4.It is a newly discovered antidepressant agent and at the same time anti-anxiety, but haven't seen any psychotomimetic (tending to produce symptoms like those of a psychosis) side effects especially on the brain and it has a very low tendency of abuse compared to other anti-depressant drugs but almost same efficacy which was proven in a study conducted in Italy.

5.Due to its being tricyclic (contains fused three-ring moiety), it is considered to be analgesic, (pain reliever) to the extent that it can be used in chronic pain and intestinal pain as well.

6.According to a rat study, it resulted to be used as energy booster. When the rats were given Tianeptine, their swimming time raised and it is also discovered to have some effects on the pathogenesis of metabolic syndrome (multiple risk conditions like increased blood pressure, too much body fat, high cholesterol level, high blood sugar level leading to heart disease, stroke and others.

7.Also, it is discovered to have higher bioavailability compared to other tricyclic agents.

8.Based on a human study conducted in Brazil, comparing tianeptine and placebo for depressed outpatients or with bipolar disorder, it was found out that tianeptine has higher response rate which also corresponds to the findings of other European studies.

COA
 

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