Details:

Local Anesthesia Prilocaine Powder 721-50-6 to Numb Tissues

Prilocaine


Basic information:

Product Name: Prilocaine 
Synonyms: 2-(propylamino)-o-propionotoluidid;2-(Propylamino)-o-propionotoluidide;2-Methyl-alpha-propylaminopropionanilide;alpha-n-Propyl-amino-2-methylpropionanilide;alpha-n-propylamino-2-methylpropionanilide;Astra 1512;Astra 1515;astra1512 
CAS: 721-50-6 
MF: C13H20N2O 
MW: 220.31 
EINECS: 211-957-0 
Product Categories: Active Pharmaceutical Ingredients;Inhibitors 
Mol File: 721-50-6.mol 


Chemical Properties:

It is a kind of needle-like crystals with the melting point being 37-38 ºC and the boiling point being 159-162 ºC (0.133kPa), and refractive index (nD20) being 1.5299. Its hydrochloride ([1786-81-8]) is a white crystalline powder. The Melting point is 167-168 ºC. It is soluble in water and ethanol, slightly soluble in chloroform. It has sour taste and bitter taste and is odorless. 


COA :
 

Application:

Application It is a kind of local anesthetic drug. The product has better efficacy than procaine and the local anesthesia intensity and speed being similar as lidocaine but with longer duration time and less toxicity as well as smaller accumulation effect. It is suitable for epidural anesthesia, conduction anesthesia and infiltration anesthesia.  


Usage And Synthesis:

Prilocaine belongs to amide local anesthetic drug with its anesthesia intensity and speed being similar as lidocaine but with a longer duration period and weaker effect on vasodilation. It has a lower toxicity than lidocaine. It is clinically for local anesthesia, especially suitable for treating patients who are not allowed to use adrenaline. 

Pharmacological

Its 3% solution has a similar local anesthesia efficacy as the anesthesia drug of 2% lidocaine together with adrenaline. It has a slow onset time which lasts about 6 ~ 7min and the duration time of about 1.5 ~ 2h. It has a strong penetration capability through mucous membranes. Adrenaline has a slightly prolonged duration of action. PPB is 55% and T1/2 of about 1.5h. It is subject to liver metabolism with its metabolites nitroso toluidine being able to oxidize hemoglobin to form methemoglobin. It can be transported to the fetus through the placenta. 

Adverse reactions

once the usage amount exceeds 600mg, methaemoglobinaemia can occur with cyanosis, tachycardia, headache, dizziness and weakness occurring. 

Advantages:

Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.

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