TIANFU CHEM--COMBRE...

TIANFU CHEM--COMBRETASTATIN A-4

TIANFU CHEM--COMBRETASTATIN A-4

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COMBRETASTATIN A-4 117048-59-6 COMBRETASTATIN A-4

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Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below:

 

1.Noble Metal Catalysts (Pt.Pd...)

2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)

3.OLED intermediates (Fluorene,Carbazole,Boric acid...)

4.Customs Synthesis

 

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Anyway ,if you need any chemicals from China ,Henan Tianfu can help you

Details:

 
Product Name: COMBRETASTATIN A-4
Synonyms: (Z)-2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]phenol,3,4,5-Trimethoxy-3hydroxy-4methoxy-(Z)-stilbene,CS-A4;Combrestatin A4( 2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol );(Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol ,98%;2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol;3-[(Z)-2-(3,4,5-Trimethoxyphenyl)ethenyl]-6-methoxyphenol;5-[(Z)-2-(3,4,5-Trimethoxyphenyl)ethenyl]-2-methoxyphenol;Combretastatin A4;(Z)-CombretastatinA4
CAS: 117048-59-6
MF: C18H20O5
MW: 316.3484
EINECS:
Product Categories: Inhibitors;Combretastatin;Anti-cancer & immunity;API
Mol File: 117048-59-6.mol
COMBRETASTATIN A-4 Structure
COMBRETASTATIN A-4 Chemical Properties
Melting point 84.5-85.5°C
storage temp. Desiccate at -20°C
solubility DMSO: >10mg/mL
color off-white
Merck 14,2494
Safety Information
Hazard Codes T
Risk Statements 23/24/25-41
Safety Statements 26-36/37-39-45
RIDADR UN 2811
HazardClass 6.1
PackingGroup Ⅲ
MSDS Information
COMBRETASTATIN A-4 Usage And Synthesis
Chemical Properties Crystalline Powder
Uses Combretastatin is a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site.
Biological Activity Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo . Acts by inhibiting tubulin polymerization (IC 50 = 2-3 μ M).
COMBRETASTATIN A-4 Preparation Products And Raw materials
 

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