Propranolol hydrochloride CAS:318-98-9 For the prophylaxis of migraine
Quick Details:
Product Name:Propranolol hydrochloride
Synonyms:(RS)-1-[(1-METHYLETHYL)AMINO]-3-(1-NAPHTHALENYLOXY)-2-PROPANOL HYDROCHLORIDE;PROPRANOLOL HCL;(+/-)-PROPRANOLOL HYDROCHLORIDE;PROPRANOLOL HYDROCHLORIDE;(+/-)-PROPANOLOL HCL;PROPANOLOL HYDROCHLORIDE;1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanohydrochloride;1-(1-naphthyloxy)-2-hydroxy-3-isopropylaminopropanehydrochloride
CAS:318-98-9
MF:C16H22ClNO2
MW:295.8
EINECS:206-268-7
Product Categories:Aromatic alcohols and diols;Intermediates & Fine Chemicals;Pharmaceuticals;API's;APIs;Amines;Aromatics;Pharmaceutical intermediate;INDERAL
Melting point:163-165 °C(lit.)
Fp:9ºC
storage temp.:2-8°C
solubility:H2O: 50 mg/mL, clear, colorless
Chemical Properties:Off-White to Light-Yellow Cyrstalline Solid
Uses:Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).
Uses:For the prophylaxis of migraine
Descripiton:
Propranolol is a nonselective beta-adrenergic receptor blocking agent possessing no other autonomic nervous system activity. It specifically competes with beta-adrenergic receptor stimulating agents for available receptor sites. When access to beta-receptor sites is blocked by propranolol, chronotropic, inotropic, and vasodilator responses to beta-adrenergic stimulation are decreased proportionately.
CERTIFICATE OF ANALYSIS
Product name |
PROPRANOLOL HCL |
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CAS |
318-98-9 |
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25 |
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2014.09.09 |
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2017.09.08 |
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Description |
White crystalline powder |
Conform |
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Rotation |
-1.0°~+1.0° |
+0.08° |
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Identification |
Should conform to the standard |
Conform |
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Melting range |
162ºC~165ºC |
163~164.5ºC |
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PH(25ºC) |
5.0~6.0 |
5.5 |
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Acidity or alkalinity |
Conform |
Conform |
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Loss on drying |
NMT0.5% |
0.2% |
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Sulphated ash |
NMT0.1% |
0.05% |
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Single substances |
≤0.1% |
0.06% |
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Total impurities |
≤0.4% |
0.25% |
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Clarity and colour of solution |
Conform |
Conform |
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Assay |
99.0~101.0% |
99.1% |
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