Dental Local Anesthesia Drugs Paracetamol 103-90-2 Pain Reliever Drug
Product Name:Paracetamol
Alias: 4-Acetamidophenol;4'-HYDROXYACETANILIDE;4-HYDROXYACETANILIDE;ACETYL-P-AMINOPHENOL
CAS: 103-90-2
EINECS: 203-157-5
M.F.: C8H9NO2
M.W.: 151.16
Product Category: Pharmaceutical raw materials and intermediates
Product content: 98.0% -102.0%
Quality Standard: cp2000/bp98/usp23
Packing Specification: 25KG / plastic woven bag or 25KG / fiber drum
Appearance: white crystal or crystalline powder
Usage: Antipyretic analgesic bulk drugs
Paracetamol Descriptions
This product is acetanilide antipyretic analgesics. By inhibiting ring oxidase and selectivity in the hypothalamus of the temperature regulating center, the synthesis of prostaglandins in peripheral vascular expansion, sweating and antipyretic effect, strength of its antipyretic effect similar to aspirin.
Paracetamol Function
Antipyretic analgesic:
This product is acetanilide antipyretic analgesics. By inhibiting ring oxidase and selectivity in the hypothalamus of the temperature regulating center, the synthesis of prostaglandins in peripheral vascular expansion, sweating and antipyretic effect, strength of its antipyretic effect similar to aspirin
COA
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Tests |
Standards |
Results |
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Appearance |
White or almost white ,crystalline powder. |
White,crystalline powder. |
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Identification |
A:IR absorption |
Complies |
Complies |
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B:UV absorption |
Complies |
Complies |
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C:TLC |
Complies |
Complies |
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Melting point |
168~172C |
169.0~170.9C |
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Water |
Not more than0.5% |
0.08% |
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Related substance |
Impurity(chloroacetanilide)not more than 10 ppm |
2ppm |
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Impurity K(4-aminophenol)not more than 50 ppm |
15 ppm |
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Impurity F(4-nitrophenol)not more than 0.05% |
Not detected |
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any other impurity not more than 0.05% |
0.01% |
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Total of other impurities not more than 0.1% |
0.02% |
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Residue on ignition |
Not more than 0.1% |
0.05% |
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Chloride |
Not more than 0.014% |
Less than 0.014% |
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Sulfate |
Not more than 0.02% |
Less than 0.02% |
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Sulfide |
Conforms |
Conforms |
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Heavy metals |
Not more than 0.001% |
Less than 0.001% |
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Free p-aminophenol |
Not more than 0.005% |
Less than 0.005% |
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Limit of P-chloroacetanilide |
Not more than 0.001% |
Less than 0.001% |
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Readily carbonizable substances |
Conforms |
Conforms |
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Residual solvents |
Residual content of acetic acid is limited by the test of loss on dryingnot more than0.5% |
0.08% |
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Assay(anhydrous basis) |
99.0~101.0% |
99.6% |
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Conclusion: Complies with USP34 / BP2011 |
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