Ibuprofen

Details:

CAS No.15687-27-1 CharacteristicWhite Crystal Powder UsageMusculoskeletal Delivery time prompt  1.specifications PharmacologyIndicationFor symptomatic treatment of rheumatoid arthritis, juvenile rheumatoid arthritis and osteoarthritis. May be used to treat mild to moderate pain and for the management of dysmenorrhea. May be used to reduce fever. Has been used with some success for treating ankylosing spondylitis, gout and psoriatic arthritis. May reduce pain, fever and inflammation of pericarditis. May be used IV with opiates to relieve moderate to severe pain. Ibuprofen lysine may be used IV to treat patent ductus arteriosus (PDA) in premature neonates.PharmacodynamicsIbuprofen is a nonsteroidal anti-inflammatory agent (NSAIA) or nonsteroidal anti-inflammatory drug (NSAID), with analgesic and antipyretic properties. Ibuprofen has pharmacologic actions similar to those of other prototypical NSAIAs, which are thought to act through inhibition of prostaglandin synthesis.Mechanism of actionThe exact mechanism of action of ibuprofen is unknown. Ibuprofen is a non-selective inhibitor of cyclooxygenase, an enzyme invovled in prostaglandin synthesis via the arachidonic acid pathway. Its pharmacological effects are believed to be due to inhibition cylooxygenase-2 (COX-2) which decreases the synthesis of prostaglandins involved in mediating inflammation, pain, fever and swelling. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Inhibition of COX-1 is thought to cause some of the side effects of ibuprofen including GI ulceration. Ibuprofen is administered as a racemic mixture. The R-enantiomer undergoes extensive interconversion to the S-enantiomer in vivo. The S-enantiomer is believed to be the more pharmacologically active enantiomer.Absorption~ 80% absorbed from GI tractTime to reach peak plasma concentration = 47 minutes (suspension...1.Ibuprofen powder2.White crystalline powder3.High quality low price4.Fast delivery5.Professional manufacturer   Analysis   NameIbuprofenOther namealpha-methyl-4-(2-methylpropyl)benzeneacetic acidAppearenceWhite crystalline powderCas15687-27-1 Assay≥99.5%SolubilityInsoluble in waterMelting point75-78°CLoss on drying≤0.5%Heavy Metal≤50ppmBoiling point 157°C (4 mmHg)vapour pressure0.000139mmHg at 25°CUsesAntipyretic analgesicGradePharmaceutical Grade Package1 kg in an aluminum foil bag, 25kg/drum.