99.2% Pure Donepezil HCl Nootropics Powder CAS 110119-84-1 Pharmaceutical Ingredient
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Basic information:
English Name: DONEPEZIL HYDROCHLORIDE
CAS: 110119-84-1
Molecular formula: C24H30ClNO3
Molecular weight: 415.95
WHAT IS Donepezil hydrochloride
Donepezil hydrochloride is a kind of therapeutic drugs for Alzheimer's disease, which belongs to the second generation of acetylcholinesterase (ChE) inhibitors for the treatment of mild or moderate Alzheimer's disease patients, compared with the same kind of drugs with low incidence of adverse reactions and curative effect obvious characteristic, is the only drug to the U.S. Food and Drug Administration guidelines for the treatment of Alzheimer's disease the standard, is the only one at the same time by the United States and Britain FDA MCA approved drug for the treatment of mild to moderate Alzheimer's disease.
It is believed that the pathogenesis of cognitive impairment in Alzheimer's disease is partly related to the low function of cholinergic neurotransmission. Donepezil can play a therapeutic role by enhancing the function of cholinergic nerve. It reversibly inhibits the hydrolysis of acetylcholine by acetylcholine esterase, thereby increasing the concentration of acetylcholine at the receptor site. According to the mechanism mentioned above, along with the progression of the disease, the functional cholinergic neurons will gradually decrease, and the effect of donepezil may be weakened. There is no evidence that donepezil can alter the underlying course of dementia.
Specification:
| ITEMS | SPECIFICATIONS | RESULTS |
| Appearance | white or almost white crystalline powder | complies |
| Solubility | conform | complies |
| Identification |
1) BY UV ABSORPTION 2) BY IR ABSORPTION |
complies complies |
| PH | 4.0-7.0 | 5.47 |
| Relative substances | ||
| Total | ≤1.80% | 0.07% |
| Single impurity (unknown) | ≤0.50% | <0.1% |
| Loss on drying | ≤1.0% | 0.03% |
| Residue on ignition | ≤0.10% | 0.08% |
| Heavy metal | ≤10 PPM | <10 PPM |
| Assay | ≥99.0% | 99.75% |
Matters needing attention:
1 , disable highly sensitive patients with donepezil or piperidine derivatives.
2, have an impact on heart disease, asthma or obstructive lung disease, also increase the risk of gastrointestinal ulcers.
3, cholinergic action may cause urinary retention and convulsions (possibly associated with primary disease) and should be observed when taking medication.
4, and succinylcholine, muscle relaxant, anticholinergic drugs have antagonistic effect, so it can not be used together.
Advantages:
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