Trelagliptin Succinate SYR-472 100mg Safety Evaluation of Powder CAS 1029877-94-8
Quick Detail:
SYR-472 is a novel once-weekly oral DPP-4 inhibitor for type 2 diabetes, which could be a treatment option when clinicians seek to improve medication adherence by reducing the number of required administrations.
| Product name | Trelagliptin succinate |
| CAS NO. | 1029877-94-8 |
| Synonyms | Trelagliptin succinate |
| Category | Pharmaceutical Raw Materials,Active Pharmaceutical Ingredients,Bulk Drugs,Fine Chemicals. |
| Purity | 99% Trelagliptin succinate |
| Appearance | Trelagliptin succinate powder |
| Shelf life | 2 years |
| Usage | Trelagliptin succinate is an antidiabetic drug. Trelagliptin succinate is used to improve glycemic control in people with type 2 diabetes |
| Storage | Trelagliptin succinate should be stored in a well-closed container at low temperature, keep away from moisture, heat and light. |
Trelagliptin Succinate Usage:
Trelagliptin(SYR-472) is a long acting dipeptidyl peptidase-4 (DPP-4) inhibitor that is being developed for the treatment of type 2 diabetes (T2D).Trelagliptin succinate is an antidiabetic drug. Trelagliptin succinate is used to improve glycemic control in people with type 2 diabetes
Trelagliptin Succinate Application:
Trelagliptin Succinate (SYR-472), a novel dipeptidyl peptidase-4 inhibitor, shows sustained efficacy by once-weekly dosing in type 2 diabetes patients.
In this study, we characterized in vitro properties of trelagliptin, which exhibited approximately 4- and 12-fold more potent inhibition against human dipeptidyl peptidase-4 than alogliptin and sitagliptin, respectively, and >10,000-fold selectivity over related proteases including dipeptidyl peptidase-8 and dipeptidyl peptidase-9. Kinetic analysis revealed reversible, competitive and slow-binding inhibition of dipeptidyl peptidase-4 by trelagliptin (t1/2 for dissociation ≈ 30 minutes).
X-ray diffraction data indicated a non-covalent interaction between dipeptidyl peptidase and trelagliptin. Taken together, potent dipeptidyl peptidase inhibition may partially contribute to sustained efficacy of trelagliptin.
Trelagliptin Succinate COA
| Item | Specification | Result |
| Appearance | Powder | Conforms |
| Color | White Powder or Crystal | Conforms |
| Mesh Size | 100% through 80% mesh size | Conforms |
| Identification | Identical to R.S. sample | Conforms |
| Trelagliptin Succinate | 99% | Conforms |
| Loss on Drying | ≤5.0% | 3.11% |
| Ash | ≤5.0% | Conforms |
| Solvents Residue | Meet Eur.Ph6.0<5.4> | Conforms |
| Pesticides Residue | Meet USP32<561> | Conforms |
| Lead(Pb) | ≤3.0mg/kg | 2.45 |
| Arsenic(As) | ≤2.0mg/kg | 1.29 |
| Cadmium(Cd) | ≤1.0mg/kg | 0.68 |
| Mercury(Hg) | ≤0.1mg/kg | 0.07 |
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