Azd-2281 Lynparza (Olaparib) CAS 763113-22-0 to Treat Advanced Ovarian Cancer
Description
| Product Name: |
Lynparza
| CAS: | 763113-22-0 |
| MF: | C21H26O3 |
| MW: | 434.46 |
| EINECS: | 259-474-4 |
| Solubility (25°C) | DMSO 86 mg/mL warming (197.94 mM) Water 0.002 mg/mL (0.0 mM) Ethanol <1 mg/mL |
Usage:Olaparib is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Olaparib has been shown to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Recent studies show that Olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy.
Lynparza is a poly ADP-ribose polymerase (PARP) inhibitor that blocks enzymes involved in repairing damaged DNA. It is intended for women with heavily pretreated ovarian cancer that is associated with defective BRCA genes.
Specification
| Item | Specifications | Results |
| Description | White powder | Conforms |
| Identification | Shall comply | All comply |
| Loss on drying | ≤0.5% | 0.1% |
| Sulphated Ash | ≤0.1% | 0.04% |
| Heavy metals | ≤0.002% | <0.002% |
| Palladium | ≤0.001% | Not examined |
|
Particle size Tapped density Loose density |
100%<60um |
Conforms 0.386g/ml 0.205g/ml |
|
Related Substances Total Impurities |
≤0.3% |
0.23% |
| Assay (on dried basis) | 98%to102.0% | 99.8% |
| Conclusion | The results conforms with EP6.0 standards | |
Application:
Olapanil is a novel poly-ADP ribose polymerase (PARP) inhibitor, including PARP1, PARP2, and PARP3. PARP mediates a mechanism of DNA repair and plays an important role in DNA damage repair and cell apoptosis. Therefore, the mechanism of DNA damage repair by targeting to cells is mediated by PARP1 and PARCA2 mutant cancer cells Of the critical loopholes in the role, can be used for breast cancer susceptibility gene (BRCA) mutations, platinum-sensitive drug-resistant patients with recurrent severe ovarian cancer maintenance therapy.
Olaparib is a kind of novel poly ADP-ribose polymerase (PARP) inhibitors, including PARP1, PARP2, and PARP3. PARP mediates a DNA-repair mechanism which plays a important role in DNA damage repair and apoptosis, so olaparib specifically targets on the DNA repair mechanism of the targeting cell DNA repair and take effects by attacking the critical vulnerabilities of cancer cells carrying mutations in BRCA1 and BRCA2. Owing to this mechanism, it can be used for the maintenance therapy of patients of severe recurrent ovarian cancer who has breast cancer susceptibility gene (BRCA) mutation as well as being sensitive to platinum drug.
Scientists from Harvard Medical School Dana - Farber Cancer Institute have found that the target site of olaparib is the polymerase Q (POLQ, also known POLθ). Those scientists found that a large number of patients of ovarian cancer has the genetic deficiency in the homologous recombination (homologous recombination, HR) repair pathway and dramatic up-regulated expression of POLQ greatly. Since HR is an important repair pathway for repairing broken DNA, they speculated that the major function of POLQ is to compensate for the lack of HR and participate in DNA repair.
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Advantages:
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Azd-2281 Lynparza (Olaparib) CAS 763113-22-0 to Treat Advanced Ovarian Cancer