Pharmaceutical Raw Material Cinacalcet Hydrochloride (CAS 364782-34-3)
Product Description
Cinacalcet hydrochloride Description
Cinacalcet hydrochloride is a naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-sensing receptors to serum calcium. This action reduces parathyroid hormone secretion and decreases serum calcium in the treatment of PARATHYROID DISEASES.
Cinacalcet Hydrochloride is the orally bioavailable hydrochloride salt of the calcimimetic cinacalcet. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone (PTH) secretion. A reduction in PTH levels inhibits osteoclast activity, which may result in a decrease in cortical bone turnover and bone fibrosis, and normalization of serum calcium and phosphorus levels. In addition, by reducing PTH levels, cinacalcet may reduce PSA levels; PTH appears to raise PSA levels and may increase prostate cancer cell growth.
Cinacalcet hydrochloride
CAS:364782-34-3
Chemical name:N-((1R)-1-(1-Naphthyl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride
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Appearance |
White or off-white crystalline powder |
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Identification |
IR/HPLC |
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Solubility |
Slightly soluble in water, soluble in MeOH |
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Melting point |
180-181°C |
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Loss on drying |
≤0.5% |
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Heavy metals |
≤20ppm |
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Residue on ignition |
≤0.1% |
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Related substance |
CF2H-Cinacalcet≤0.7% Any other impurity≤0.25% |
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e.e.(HPLC) |
≥99.0% |
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Purity(HPLC) |
≥99.0% |
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Pharmaceutical Raw Material Cinacalcet Hydrochloride (CAS 364782-34-3)