Active Pharmaceutical Ingredients Roxithromycin CAS 80214-83-1 for Antibacterial

Details:

• Quick Details of Active Pharmaceutical Ingredients Roxithromycin

 

Active Pharmaceutical Ingredients Roxithromycin CAS 80214-83-1 for Antibacterial

Product Name: Roxithromycin

Synonyms: ROXITHROMYCIN;ERYTHROMYCIN 9-(-O-[2-METHOXYETHOXY]METHYLOXIME);ERYTHROMYCIN, 9-[O-[(2-METHOXYETHOXY)METHYL]OXIME], (9E)-;Roxithromycin CP2000;Roxithromycin EP;RoxithromycinEp/Bp/CpC41H76N2O15;RoxithromycinC41H76N2O15;(9E)-9-[O-[(2-Methoxyethoxy)methyl]oxime] Erythromycin;

 

CAS: 80214-83-1;

MF: C41H76N2O15;

MW: 837.05.

 

Product name:	Roxithromycin
Other Name:	9-(-O-[2-METHOXYETHOXY]METHYLOXIME);ERYTHROMYCIN, 9-[O-[(2-METHOXYETHOXY)METHYL]OXIME], (9E)-;Roxithromycin CP2000;Roxithromycin EP;RoxithromycinEp/Bp/CpC41H76N2O15;RoxithromycinC41H76N2O15;(9E)-9-[O-[(2-Methoxyethoxy)methyl]oxime] Erythromycin;
Original:	China
CAS:	80214-83-1
Molecular formula:	C41H76N2O15
MW:	837.05
Brand name	NJBNSteroid
Leading time	within 24 hours upon receipt of payment
Delivery	Fast and secure shipping by EMS, DHL, TNT, FedEx, UPS
Purity	99%
Package	Discreet and Hidden package according to specific requirement
Appearance	White Powder
Certification	SGS, ISO 9001, KOSHER
Payment Terms	, Money Gram , T/T, Bitcoin
Minimum Order Quantity	10g
Price	Negotiable
Usage	Roxithromycin was one of the new generation erythromycins introduced in the 1980s. Improved acid stability was achieved by converting the 9-keto group to the more stable oxime and alkylation of the oxime to provide the methoxyethoxymethyl ether oxime. In vivo, roxithromycin exhibits higher tissue levels and a longer half-life while being slightly less potent than erythromycin in vitro.
Molecular structure

 

• Overview of Active Pharmaceutical Ingredients Roxithromycin

 

Roxithromycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

 

• What is Roxithromycin Used for

 

Roxithromycin is used to treat:

 

1. some respiratory tract infections

2. pneumonia (lung infection).

 

Roxithromycin can also be used for treating skin infections caused by other bacteria.

People who are generally unwell, or have an ongoing health condition such as the ones listed below, are at greater risk of complications. They are more likely to benefit from antibiotics than other people.

 

This medicine is used to treat various infections caused by bacteria such as:

(1) acute pharyngitis (sore throat and discomfort when swallowing)

(2) tonsillitis

(3) sinusitis

(4) acute bronchitis (infection of the bronchi causing coughing)

(5) exacerbation of chronic bronchitis

(6) pneumonia (lung infection characterised by fever, malaise, headache)

(7) skin and soft tissue infections

(8) non gonococcal urethritis

(9) impetigo (bacterial infection causing sores on the skin).

It contains the active ingredient roxithromycin. Roxithromycin belongs to a group of medicines called macrolides.

It works by killing or stopping the growth of the bacteria that are causing the infection.

However, Roxithromycin Sandoz does not have any effect on viral infections such as the flu.

 

• Technical Test Sheet of Active Pharmaceutical Ingredients Roxithromycin

 

Items	Requirements	Results
Appearance	A white or almost white crystalline powder	A white crystalline powder
Specific rotation	-82°~-87°	-85.8°
Identification (IR)	(1)should be consistent for the trying solution prominent peak retention time with the comparison solution prominent peak retention time	Consistent
	(2)this infrared light absorption atlas should be consistent with the comparison atlas	Consistent
related substance	The single impurity peak area does not have to be bigger than the comparison solution prominent peak area 1.5 times	0.9
	Each miscellaneous quality area of with can not be big in check against aqua a lord the area of 4.5times	4.2
Alkalinity pH	8.0~10.0	9.0
Water	less than 3.0%	2.8%
Residue on ignition	less than 0.1%	0.06%
Heavy metals	less than 10ppm	less than 10ppm
on the anhydrous basis	more than 94.0%	95.9%
Conclusion	The material conform with BP2010

 

• How to take Active Pharmaceutical Ingredients Roxithromycin

 

(1) Take roxithromycin at the same time each day.

(2) Roxithromycin is best taken on an empty stomach, about 15 minutes before food. If it makes you feel sick, then take it with food.

(3) Keep taking roxithromycin until you finish all the tablets, for as long as your doctor or pharmacist tells you to.

(4) Do not stop taking roxithromycin, even if you feel better after a few days, unless your doctor tells you to.

(5) If you forget to take roxithromycin, take it as soon as you remember.

(6) But, if it is nearly time for your next dose, just take the next dose at the right time. Do not take double the dose.

 

• Pharmacology of Active Pharmaceutical Ingredients Roxithromycin

 

Roxithromycin is a semi-synthetic macrolide antibiotic. It is very similar in composition, chemical structure and mechanism of action to erythromycin, azithromycin, or clarithromycin. Roxithromycin has the following antibacterial spectrum in vitro: Streptococcus agalactiae,Streptococcus pneumoniae (Pneumococcus), Neisseria meningitides (Meningococcus), Listeria monocytogenes, Mycoplasma pneumoniae, Chlamydia trachomatis, Ureaplasma urealyticum,Legionella pneumophila, Helicobacter (Campylobacter), Gardnerella vaginalis, Bordetella pertussis, Moraxella catarrhalis (Branhamella Catarrhalis), and Haemophilus ducreyi. Roxithromycin is highly concentrated in polymorphonuclear leukocytes and macrophages, achieving intracellular concentrations greater than those outside the cell. Roxithromycin enhances the adhesive and chemotactic functions of these cells which in the presence of infection produce phagocytosis and bacterial lysis. Roxithromycin also possesses intracellular bactericidal activity.

 

• Mechanism of Action of Active Pharmaceutical Ingredients Roxithromycin

 

Roxithromycin prevents bacteria from growing, by interfering with their protein synthesis. Roxithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides. Roxithromycin has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.

 

• Toxicity of Active Pharmaceutical Ingredients Roxithromycin

 

Most common side-effects are gastrointestinal; diarrhoea, nausea, abdominal pain and vomiting. Less common side-effects include headaches, rashes, abnormal liver function values and alteration in senses of smell and taste.

 

 

 

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Active Pharmaceutical Ingredients Roxithromycin CAS 80214-83-1 for Antibacterial