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99%min Atazanavir For Antibiotic API Manufacturer
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Atazanavir Basic information |
Product Name: | Atazanavir |
Synonyms: | ATAZANAVIR, BISULFATE SALT;Atazanavir;(3S,8S, 9S, 12S)-2,5,6,13-Pentaazatetradecanedioic Acid;3,12-Bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenylmethyl)-6-[[4-(2-pyridinyl)phenyl]methyl]-dimethyl Ester;Methyl N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[[[(2S)-2-(methoxycarbonylamino)-3,3-dimethylbutanoyl]amino]-[(4-pyridin-2-ylphenyl)methyl]amino]-1-phenylbutan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]carbamate;(2S)-N-(3-{[(2S)-2-(Methoxycarbonylamino)-3,3-dimethylbutanoylamino][(4-(2-pyridyl)phenyl)methyl]amino}(1S,2S)-2-hydroxy-1-benzylpropyl)-2-(methoxycarbonylamino)-3,3-dimethylbutanamide;229975-97-7 (Sulfate 1:1);Aids057755 |
CAS: | 198904-31-3 |
MF: | C38H52N6O7 |
MW: | 704.87 |
EINECS: | |
Product Categories: | API;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents;Inhibitor;peptides |
Mol File: | 198904-31-3.mol |
Atazanavir Chemical Properties |
Melting point | 207-2090C |
alpha | D -47° (c = 1 in ethanol) |
storage temp. | -20°C Freezer |
Safety Information |
Hazardous Substances Data | 198904-31-3(Hazardous Substances Data) |
Atazanavir Usage And Synthesis |
Chemical Properties | Crystalline Solid |
Uses | Atazanavir is a novel azapeptide protease inhibitor (PI) |
Uses | enzyme inhibitor |
Uses | Atazanavir is a novel azapeptide HIV protease inhibitor (PI). Antiviral. |
Definition | ChEBI: A heavily substituted carbohydrazide that is an antiretroviral drug of the protease inhibitor (PI) class used to treat infection of human immunodeficiency virus (HIV). |
Uses | Atazanavir is an inhibitor of HIV-1 protease (EC50 = 2.6 nM). In isolated cells, it has additive to moderately synergistic antiviral effects when combined with other antiretroviral drugs. As a result, it is commonly used in vivo in combination therapy for HIV-1 infection. Atazanavir competitively inhibits UDP-gluronosyltransferase, which conjugates bilirubin for clearance, leading to hyperbilirubinemia in a significant portion of those receiving atazanavir therapy. |
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