99% Vandetanib CAS: 443913-73-3 Pharmaceutical Grade
Product Description
Basic information
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CAS NO. |
443913-73-3 |
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Product Name |
Vandetanib |
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Synonyms |
4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline; |
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Purity |
99% |
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Molecular Formula |
C22H24BrFN4O2 |
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Molecular Weight |
475.353963 |
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Flash Point |
279.3 °C |
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InChI |
InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) |
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Boiling Point |
538.2 °C at 760 mmHg |
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Solubility |
Soluble in DMSO |
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Density |
1.406g/cm3 |
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Melting Point |
240-243ºC |
Chemical Properties:
|
|
443913-73-3 |
Storage |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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M.Wt |
475.35 |
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Formula |
C22H24BrFN4O2 |
Specification:99%
Testing Method:HPLC
Appearance:White fine powder
Introduction:
Vandetanib (INN, trade name Caprelsa) is an anti-cancer drug that is used for the treatment of certain tumours of the thyroid gland.It acts as a kinase inhibitor of a number of cell receptors, mainly the vascular endothelial growth factor receptor (VEGFR), the epidermal growth factor receptor(EGFR), and the RET-tyrosine kinase.The drug was developed by AstraZene
Function
An anticancer drug that is used for the treatment of certain tumours of the thyroid gland.It acts as a kinase inhibitor of a number of cell receptors, mainly the vascular endothelial growth factor receptor (VEGFR), the epidermal growth factor receptor (EGFR), and the RET-tyrosine kinase.Vandetanib is an orally active small molecule tyrosine kinase inhibitor (TKI) with activity against several pathways implicated in malignancy including the vascular endothelial growth factor receptor pathway, the epidermal growth factor receptor pathway, the platelet derived growth factor receptor pathway, and REarranged during Transfection pathway.
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