1258-84-0 pristimerin pristimerin
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Product Name: | pristimerin |
Synonyms: | pristimerin;3-Hydroxy-2-oxo-24-nor-D:A-friedoolean-1(10),3,5,7-tetren-29-oic acid methyl ester;Celastrol-methylether;(9b,13a,14b,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tertraen-29-oic acid methyl ester;(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oicacidmethylester;3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid, methyl ester;Celastrol methyl ester;Pristimerin(NSC 99281) |
CAS: | 1258-84-0 |
MF: | C30H40O4 |
MW: | 464.642 |
EINECS: | |
Product Categories: | |
Mol File: | 1258-84-0.mol |
pristimerin Chemical Properties |
storage temp. | Store at -20°C |
solubility | DMSO: ≥5mg/mL |
color | orange |
Safety Information |
pristimerin Usage And Synthesis |
Uses | antineoplastic, antiinflammatory |
Uses | Pristimerin is a triterpenoid that inhibits tumor angiogenesis by targeting VEGFR2 activation and is known to exhibit anti-inflammatory properties. |
Biological Activity | Potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC 50 = 93 nM). Also suppresses NF- κ B activation via inhibition of proteasome chymotrypsin-like activity and IKK α / β . Displays antitumor, anti-inflammatory and antimicrobial activities. |
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