DAURICINE Basic information
Description References
Product Name: DAURICINE
Synonyms: -(4-((1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl)phenox;(r-(r*,r*))-y);4-[[(1R)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]phenol;4-[((1R)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl)methyl]-2-[4-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl]methyl]phenoxy]phenol;Dauricine;dauricine (8ci);Menispermum dauricum DC Extract;6,6'-Di-O-Methyldauricoline
CAS: 524-17-4
MF: C38H44N2O6
MW: 624.774
EINECS:
Product Categories: Alkaloids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File: 524-17-4.mol
DAURICINE Structure
DAURICINE Chemical Properties
Melting point 115°
alpha D11 -139° in methanol
Safety Information
MSDS Information
DAURICINE Usage And Synthesis
Description As a plant metabolite, Dauricine is a bioactive component derived from Asiatic Moonseed Rhizome and Canadian moonseed, which has been widely used in the treatment of a variety of inflammatory diseases especially in traditional Chinese medicine. It was first synthesized by the scientists from Japan in 1964.
It has been proved that Dauricine plays a number of biological roles in the human body, from inhibiting cancer cell growth to blocking cardiac transmembrane Na+, K+, and Ca2+ ion currents. Recent studies suggested that there is novel role of dauricine in preventing or treating cancer. It has been shown to have anti-tumor effects in several cancers, including colon cancer, breast cancer, urinary cancers such as bladder cancer and prostate cancer.
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Definition ChEBI: A bisbenzylisoquinoline alkaloid resulting from the formal oxidative dimerisation of 4-{[(1R)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}phenol by attachment of the phenolic oxygen of one molecule to the benzene ring f the second (ortho to the phenolic hydroxy group of the latter).
DAURICINE Preparation Products And Raw materials