Pharmaceutical Raw Material Tamsulosin Hydrochloride CAS 106463-17-6
1. Quick Details:
Product name: Tamsulosin hydrochloride
Synonyms:Benzenesulfonamide,5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-,monohydrochloride (9CI);Benzenesulfonamide,5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-, monohydrochloride,(R)-;(-)-YM 12617;(R)-(-)-YM 12617;Flomax;Harnal;LY 253351;Omic;Omnic;YM 12617-1;YM 617;Yutanal;Tamsulosin HCl;
CAS Number:106463-17-6
Appearance: white to off-white solid
Assay: 99%
Molecular weight: 444.97
Molecular Formula: C20H28N2O5S.HCl
Melting Point: 228-230 °C
Boiling Point: 595.5 °C at 760 mmHg
Flash Point:313.9 °C
Using: Used in the treatment of prostate hyperplasia.
2. Product Description:
Tamsulosin is a selective α1 receptor antagonist that has preferential selectivity for the α1A receptor in the prostate versus the α1B receptor in the blood vessels.
When alpha 1 receptors in the bladder neck and the prostate are blocked, this causes a relaxation in smooth muscle and therefore less resistance to urinary flow. Due to this the pain associated with BPH can be reduced.
3. Application:
It is used in the treatment of difficult urination, a common symptom of enlarged prostate. Tamsulosin, and other medications in the class called alpha blockers, work by relaxing bladder neck muscles and muscle fibers in the prostate itself and make it easier to urinate.
4. Specification:
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Items |
Specification |
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Characteristics |
White or almost white crystalline powder, Slightly soluble in water, freely soluble in formic acid,slightly soluble in anhydrous ethanol. |
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Melting point |
about 230°C |
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Identification |
1) should conformed 2) specific rotation: -17.5° to -20.5° 3) examine by infrared absorption spectrophotometry,compare the spectrum obtained with reference spectrum:should meet the requirements 4) should conformed |
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Related substances |
Method A (EP method): Largest single impurity should ≤0.1% Method B(EP method): Largest single impurity should≤0.1% Total impurities should ≤0.2% |
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Enantiomeric purity |
≤0.1% |
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Heavy metals |
≤20ppm |
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Loss on drying |
≤0.5% |
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Sulphated ash |
≤0.1% |
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Assay |
98.5% ~ 101.0%
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Advantages:
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