C31H48O2S2 Probu...

C31H48O2S2 Probucol 23288-49-5

C31H48O2S2 Probucol 23288-49-5

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1 Metric Ton

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  • Min.Order :1 Metric Ton
  • Purity: 99.5%
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Probucol 23288-49-5 C31H48O2S2

Quick Details

  • Appearance:Powder
  • Application:23288-49-5
  • PackAge:Aluminium Foil Bag and Paper Drum
  • ProductionCapacity:100|Metric Ton|Day
  • Storage:1MT
  • Transportation:By Sea/Air/DHL

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Details:

 
Probucol Basic information
Description References
Product Name: Probucol
Synonyms: PROBUCOL;4,4’-((1-methylethylidene)bis(thio))bis(2,6-bis(1,1-dimethylethyl)-pheno;biphenabid;bisbid;bisphenabid;dh581;4,4'-ISOPROPYLIDINEDITHIO-BIS-(2,6-DI-TERT-BUTYL)PHENOL;4-({1-[(4-hydroxy-3,5-di-t-butylphenyl)thio]-1-methylethyl}thio)-2,6-di-t-butylphenol
CAS: 23288-49-5
MF: C31H48O2S2
MW: 516.84
EINECS: 245-560-9
Product Categories: Cardiovascular;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;API;LORELCO;Isolabel;Cardiovascular APIs
Mol File: 23288-49-5.mol
Probucol Structure
 
Probucol Chemical Properties
Melting point  126-128°C
storage temp.  Desiccate at +4°C
Merck  14,7755
CAS DataBase Reference 23288-49-5(CAS DataBase Reference)
 
Safety Information
RTECS  AL3705000
MSDS Information
 
Probucol Usage And Synthesis
Description Probucol is a kind of bis-phenol antioxidant with anti-hyperlipidemic activity. It had been initially developed for the treatment of coronary artery disease. However, its clinical trials were stopped after people found that it could lower the HDL and LDL cholesterol in patients of a history of heart disease. Probucol exerts its effect through accelerating the fractional rate of low-density (LDL) catabolism which is in the final pathway of cholesterol elimination inside the body. It may also inhibit the early stage of cholesterol biosynthesis and dietary cholesterol absorption.
References #
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Chemical Properties White Solid
Uses antihyperlipidemic
Uses Probucol is an antilipemic.
Uses anti-hyperlipoproteinemic
Uses An antioxidant, anti-inflammatory, and hypocholesterolemic agent which inhibits atherogenesis in murine models.
Definition ChEBI: A dithioketal that is propane-2,2-dithiol in which the hydrogens attached to both sulfur atoms are replaced by 3,5-di-tert-butyl-4-hydroxyphenyl groups. An anticholesteremic drug with antioxidant and anti-inflammatory properties, it is used to treat high l vels of cholesterol in blood.
Biological Activity Antioxidant, anti-inflammatory and hypocholesterolemic agent. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis.
 
Probucol Preparation Products And Raw materials
Raw materials Sodium bicarbonate-->Disulfur dichloride-->2,6-Di-tert-butylphenol-->2,6-Di-tert-butyl-4-mercaptophenol

 

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