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DEMETHOXYCURCUMIN 22608-11-3 C20H18O5
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DEMETHOXYCURCUMIN Basic information |
Product Name: | DEMETHOXYCURCUMIN |
Synonyms: | Feruloyl-P-hydroxycinnnamoylmethane;Demethoxycurcumin;1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione;1,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-;MonodeMethoxycurcuMin;(1E,6E)-1-(4-Hydroxyphenyl)-7-(4-hydroxy-3-Methoxyphenyl)-1,6-heptadiene-3,5-d;(E,E)-1-(4-Hydroxy-3-Methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione;1-(4-Hydroxy-3-Methoxyphenyl)-7-(p-hydroxyphenyl)-1,6-heptadiene-3,5-dione |
CAS: | 22608-11-3 |
MF: | C20H18O5 |
MW: | 338.35 |
EINECS: | |
Product Categories: | Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals |
Mol File: | 22608-11-3.mol |
DEMETHOXYCURCUMIN Chemical Properties |
storage temp. | 2-8°C |
solubility | DMSO: ≥10mg/mL |
color | orange |
Safety Information |
Hazard Codes | N |
Risk Statements | 50 |
Safety Statements | 61 |
RIDADR | UN 3077 9 / PGIII |
HS Code | 29145090 |
DEMETHOXYCURCUMIN Usage And Synthesis |
Uses | The demethoxy derivative of Curcumin (C838500) that regulates anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. It attenuates the Wnt/β-catenin pathway through do wn-regulation of the transcriptional coactivator p300. |
Uses | Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin. More stable than curcumin in physiological media, DMC suppresses proliferation in cancer cells at 50-100 μM. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits lipopolysaccharide induction of iNOS. |
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