TIANFU CHEM Rocuronium bromide

Details:

Product Name: Rocuronium bromide
Synonyms: ROCURONIUM BROMIDE;[3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enyl-2,3,4,5-tetrahydropyrrol-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl] acetate bromide;ROCURONIUN BROMIDE;1-[(2b,3a,5a,16b,17b)-17-(Acetyloxy)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl]-1-(2-propenyl)pyrrolidinium Bromide;Esmeron;Org-9426;Zemuron;Rocuronium Bromide／1-[17B-(acetyloxy)-3a-hydroxy2B-(4-morpholinyl)-5a-androstan-16B-yl]-1-(2-propenyl)pyrrolidinium bromide
CAS: 119302-91-9
MF: C32H53BrN2O4
MW: 609.68
EINECS: 214-776-5
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Acetylcholine receptor;Heterocycles;Steroids;Steroid and Hormone
Mol File: 119302-91-9.mol
Rocuronium bromide Structure
Rocuronium bromide Chemical Properties
Melting point  162-1640C
alpha  D20 +18.7° (c = 1.03 in CHCl3)
storage temp.  Room temp
solubility  H2O: soluble100mg/mL, clear, light yellow
Merck  14,8246
CAS DataBase Reference 119302-91-9(CAS DataBase Reference)

Rocuronium bromide Usage And Synthesis
Non-depolarizing muscle relaxants Rocuronium bromide, together with pancuronium, vecuronium, atracurium, and pipecuronium are current commonly used several kinds of clinically non-depolarizing muscle relaxants with Rocuronium bromide having the fastest onset which can provide the ideal conditions of muscle relaxant within 60~90 s. The binding between non-depolarizing muscle relaxants with motor endplate cholinergic receptor will not change the membrane potential of the motion endplate, but instead hinder the binding between acetylcholine and its receptors, and making muscle relaxation occur. The muscle relaxant drugs in the event before, unlike depolarizing muscle relaxants, won’t lead to muscle twitching caused by the contraction of muscle fiber bundles before the occurrence of muscle relaxation.
Rocuronium bromide is the derivative of vecuronium, and they have similar role. However, the strength of Rocuronium bromide is only one seventh of that of vecuronium. Intravenous injection of it has a rapid onset, with the cannula can be carried out within 60 to 90 seconds and the action being lasted as long as 30 to 40 minutes. It has no significant effect on vegetation nervous and cardiovascular, but can reduce the intraocular pressure. It has no histamine release effect and sympathetic ganglion blocking effect. It is commonly used in clinical tracheal intubation, can also be used for the maintenance of muscle relaxation in various kinds of surgeries. When being applied to cannula, use a single injection of 0.6mg/kg and a maintenance dose of 0.15mg/kg. This product can have cross-allergic reaction with other muscle relaxants, and thus should be used with caution. Patients of liver and kidney dysfunction and the elderly people should use with caution.