API Tenofovir CAS 147127-20-6 For Anti-HIV Pharma Raw Materials
Tenofovir
CAS: 147127-20-6
MF: C9H14N5O4P
MW: 287.21
mp 276-280°C
storage temp. Store at -20°C
Water Solubility 13.4 mg/mL (25 oC)
Chemical Properties White Crystalline Solid
Usage Acyclic phosphonate nucleotide analogue. Used as an anti-HIV agent
Usage Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.
Purity: 99%
Usage: API
Package: 1KG foil bag; 25Kg drum
Tenofovir Usage And Synthesis
1. Antiviral drugs, Tenofovir is an acyclic nucleoside antiviral reverse transcriptase inhibitor. The active substance is Tenofovir disoproxil, while tenofovir is a prodrug that is used because of its better absorption in the gut.
2. Tenofovir can inhibit viral polymerase through direct competitively combine with natural deoxyribose or by insertion to terminate chain of human DNA. It is the first nucleotide analogs to treat HIV-1 infection that approved by the US Food and Drug Administration (FDA).
3. Tenofovir is a main medicine in AIDS cocktail therapy, researches has shown that it can effectively improve the monkeys` ability on prevention of immunodeficiency virus (similar to the human AIDS virus).
COA
|
Items of analysis |
Specification |
Results |
|
Appearance |
White powder or off-white powder |
White Powder |
|
Identification |
Must conform to reference standard |
Conforms |
|
Water |
NMT3.0% |
1.53% |
|
Residue on ignition |
NMT2.0% |
1.07% |
|
Specific Rotation |
-19.0°~-23.0° |
-22.5° |
|
Sulphated ash |
≤1.5% |
0.27% |
|
Single impurity |
≤1.0% |
0.29% |
|
Total impurity |
≤3.0% |
1.11% |
|
Assay(Titrimetry) |
98.0%-102% |
98.60% |
|
9-Propenyl adenine |
≤100ppm |
Conforms |
|
PMPA Monoester Impurity |
≤1.5% |
0.35% |
|
Conclusion |
Qualified |
|
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