top Fasudil hydroch...

top Fasudil hydrochloride

top Fasudil hydrochloride

Min.Order / FOB Price:Get Latest Price

1 Gram

FOB Price: USD 1.0000

  • Min.Order :1 Gram
  • Purity: 99%
  • Payment Terms : L/C,T/T,

Keywords

Fasudil hydrochloride high purity Fasudil hydrochloride factory supply Fasudil hydrochloride

Quick Details

  • Appearance:Colorless to light yellow liquid
  • Application:Used in a base-free iridium-catalyzed direct alkylation of active methylene compounds with alcohols.1
  • PackAge:as you requested
  • ProductionCapacity:10|Kilogram|Day
  • Storage:room temperature
  • Transportation:by courier

Superiority:

Our company was built in 2009 with an ISO certificate.In the past 5 years, we have grown up as a famous fine chemicals supplier in China and we had established stable business relationships with Samsung,LG,Merck,Thermo Fisher Scientific and so on.Our main business covers the fields below:
 
1.Noble Metal Catalysts (Pt.Pd...)
2.Organic Phosphine Ligands (Tert-butyl-phosphine.Cyclohexyl-phosphine...)
3.OLED intermediates (Fluorene,Carbazole,Boric acid...)
4.Customs Synthesis
 
Our advantage:
 
1. Higest quality and good package 
2.Fast delivery 
3.Better payment term 
4.Fast response to customer  within 6 hours 
5.Good business credit in Europe ,US ,Japan ,Korea 
 
Anyway ,if you need any chemicals from China ,Henan Tianfu can help you

Details:

Product Name: Fasudil hydrochloride
Synonyms: 1-(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE;(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE, 2HCL;5-(1,4-DIAZEPAN-1-YLSULFONYL)ISOQUINOLINE HYDROCHLORIDE;HEXAHYDRO-1-(5-ISOQUINOLINYLSULFONYL)-MONOHYDROCHLORIDE;HA-1077;HA-1077 DIHYDROCHLORIDE;FASUDEL;FASUDIL DIHYDROCHLORIDE
CAS: 105628-07-7
MF: C14H18ClN3O2S
MW: 327.83
EINECS:  
Product Categories: APIs;API;Inhibitor;Cardiovascular & Blood System Agents;Inhibitors
Mol File: 105628-07-7.mol
Fasudil hydrochloride Structure
 
Fasudil hydrochloride Chemical Properties
Melting point  220.5°; mp 219.3° (Shirotani)
solubility  H2O: >200 mg/mL
form  solid
color  white
Water Solubility  Soluble in water and dimethyl sulfoxide. Insoluble in ethanol.
Merck  14,3942
CAS DataBase Reference 105628-07-7(CAS DataBase Reference)
 
Safety Information
Risk Statements  22
Safety Statements  36-60
WGK Germany  3
RTECS  HM4031166
MSDS Information
Provider Language
SigmaAldrich English
 
Fasudil hydrochloride Usage And Synthesis
Indications and Usage Fasudil Hydrochloride is a new drug with a wide range of pharmacological effects, developed by Asahi Kasei Corporation (Japan.) It is a cardiovascular and cerebrovascular drug which improves symptoms of ischemic cerebrovascular disease such as cerebral vasospasm following subarachnoid hemorrhage. It has significant neuroprotective and therapeutic effects for ischemic cerebrovascular disease, and is suited for clinical use, particularly at the grassroots level to reduce mortality and improve quality of life.
Mechanisms of Action Fasudil Hydrochloride is an isoquinoline sulfonamide derivative which can relax separated cerebral blood vessels, inhibit the shrinkage of separated blood vessels caused by calcium influx, inhibit different mechanisms of brain blood vessel contraction from contractile agents, and inhibit intracellular calcium ion activity without reducing calcium ion concentration. Fasudil Hydrochloride is an RHO kinase inhibitor which dilates vessels, reduces tension of endothelial cells, and improves microcirculation of brain tissue without producing or exacerbating diversion of blood to the brain, by increasing activity of myosin light chain phosphatase. At the same time, it can protect nerves against apoptosis and promote their regeneration. Fasudil Hydrochloride promotes recovery of neural function and reduces clinical symptoms.
Adverse reactions Adverse reactions after use can include intracranial hemorrhage, gastrointestinal bleeding, pulmonary hemorrhage, nasal bleeding, subcutaneous bleeding, and loss of consciousness, etc., as well as abnormal liver function. Low blood pressure, anemia, leukopenia, renal dysfunction, polyuria, rashes, and fever, etc. occur occasionally.
Warnings and Precautions Patients with intracranial hemorrhage or possibility thereof, or low blood pressure, should not use. Patients with diabetes mellitus, cerebral arterial sclerosis, severe disturbance of consciousness, subarachnoid hemorrhages with cerebrovascular disorders, and liver or kidney dysfunction, or those over 70 years old, pregnant, or children should use with caution. Breastfeeding women should stop while using the drug. Fasudil Hydrochloride can only be administered via intravenous drip.
Uses vasodilator, potent Rho-kinase inhibitor

 

View All
Visit Store

You Might Also Like

Related Searches

Contact Supplier

Confirm to collect the product to my collection?

OKCancel

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View