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Fluticasone propionate high purity Fluticasone propionate factory supply Fluticasone propionate
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- Appearance:Crystalline
- Application:Pharmaceutical intermediates
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Details:
| Product Name: | Fluticasone propionate |
| Synonyms: | s-fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate;-17-(1-oxopropoxy)-,s-(fluoromethyl)ester,(6-alpha,11-beta,16-alpha,17-alph;androsta-1,4-diene-17-carbothioicacid,6,9-difluoro-11-hydroxy-16-methyl-3-oxo;cci18781;fluticasone17-propionate;flutide;(6A,11B,16A,17A)-6,9-DIFLUORO-11-HYDROXY-16-METHYL-3-OXO-17-(1-OXOPROPOXY)ANDROSTA-1,4-DIENE-17-CARBOTHIOIC ACID FLUOROMETHYL ESTER;(6 ALPHA,11 BETA,16 ALPHA,17 ALPHA)-6,9-DIFLUORO-11-HYDROXY-16-METHYL-3-OXO-17-(1-OXOPROPOXY)ANDROSTA-1,4-DIENE-17-CARBOTHIOIC ACID FLUOROMETHYL ESTER |
| CAS: | 80474-14-2 |
| MF: | C25H31F3O5S |
| MW: | 500.57 |
| EINECS: | |
| Product Categories: | Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Fluticasone;Steroid and Hormone;HIVID;Hormone Drugs |
| Mol File: | 80474-14-2.mol |
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| Fluticasone propionate Chemical Properties |
| Melting point | 275 °C |
| alpha | D +30° (c = 0.35) |
| refractive index | 31 ° (C=1, Dioxane) |
| storage temp. | Store at RT |
| solubility | DMSO: ≥10 mg/mL |
| form | solid |
| color | white |
| Merck | 14,4211 |
| InChIKey | WMWTYOKRWGGJOA-CENSZEJFSA-N |
| CAS DataBase Reference | 80474-14-2(CAS DataBase Reference) |
| Safety Information |
| Safety Statements | 22-24/25 |
| WGK Germany | 2 |
| RTECS | BV7980000 |
| HS Code | 29372900 |
| MSDS Information |
| Provider | Language |
|---|---|
| Fluticasone propionate | English |
| SigmaAldrich | English |
| Fluticasone propionate Usage And Synthesis |
| Chemical Properties | Crystalline Solid |
| Uses | An antiallergic and anti inflammatory |
| Uses | A derivative of Flumethasone. An antiallergic; anti-asthmatic; anti-inflammatory. |
| Uses | antiviral |
| Uses | Atorvastatin Intermediate |
| Uses | A high-affinity, selective glucocorticoid receptor agonist |
| Definition | ChEBI: A trifluorinated corticosteroid that consits of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a propionyl s bstituent at position 17; has anti-inflammatory, anti-asthmatic and anti-allergic activity. |
| Biological Activity | High affinity, selective glucocorticoid receptor agonist (K d = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC 50 = 3.7 nM) in vitro . Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic, clinically-used anti-inflammatory agent with low oral bioavailability. |
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