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1 Gram

FOB Price: USD 1.0000

  • Min.Order :1 Gram
  • Purity: 99% min
  • Payment Terms : L/C,T/T,

Keywords

Fluticasone propionate high purity Fluticasone propionate factory supply Fluticasone propionate

Quick Details

  • Appearance:Crystalline
  • Application:Pharmaceutical intermediates
  • PackAge:as you requested
  • ProductionCapacity:10|Kilogram|Day
  • Storage:Room temperature
  • Transportation:by courier

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Details:

Product Name: Fluticasone propionate
Synonyms: s-fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate;-17-(1-oxopropoxy)-,s-(fluoromethyl)ester,(6-alpha,11-beta,16-alpha,17-alph;androsta-1,4-diene-17-carbothioicacid,6,9-difluoro-11-hydroxy-16-methyl-3-oxo;cci18781;fluticasone17-propionate;flutide;(6A,11B,16A,17A)-6,9-DIFLUORO-11-HYDROXY-16-METHYL-3-OXO-17-(1-OXOPROPOXY)ANDROSTA-1,4-DIENE-17-CARBOTHIOIC ACID FLUOROMETHYL ESTER;(6 ALPHA,11 BETA,16 ALPHA,17 ALPHA)-6,9-DIFLUORO-11-HYDROXY-16-METHYL-3-OXO-17-(1-OXOPROPOXY)ANDROSTA-1,4-DIENE-17-CARBOTHIOIC ACID FLUOROMETHYL ESTER
CAS: 80474-14-2
MF: C25H31F3O5S
MW: 500.57
EINECS:  
Product Categories: Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Fluticasone;Steroid and Hormone;HIVID;Hormone Drugs
Mol File: 80474-14-2.mol
Fluticasone propionate Structure
 
Fluticasone propionate Chemical Properties
Melting point  275 °C
alpha  D +30° (c = 0.35)
refractive index  31 ° (C=1, Dioxane)
storage temp.  Store at RT
solubility  DMSO: ≥10 mg/mL
form  solid
color  white
Merck  14,4211
InChIKey WMWTYOKRWGGJOA-CENSZEJFSA-N
CAS DataBase Reference 80474-14-2(CAS DataBase Reference)
 
Safety Information
Safety Statements  22-24/25
WGK Germany  2
RTECS  BV7980000
HS Code  29372900
MSDS Information
Provider Language
Fluticasone propionate English
SigmaAldrich English
 
Fluticasone propionate Usage And Synthesis
Chemical Properties Crystalline Solid
Uses An antiallergic and anti inflammatory
Uses A derivative of Flumethasone. An antiallergic; anti-asthmatic; anti-inflammatory.
Uses antiviral
Uses Atorvastatin Intermediate
Uses A high-affinity, selective glucocorticoid receptor agonist
Definition ChEBI: A trifluorinated corticosteroid that consits of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a propionyl s bstituent at position 17; has anti-inflammatory, anti-asthmatic and anti-allergic activity.
Biological Activity High affinity, selective glucocorticoid receptor agonist (K d = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC 50 = 3.7 nM) in vitro . Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic, clinically-used anti-inflammatory agent with low oral bioavailability.

 

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