TRICHOSTATIN A high purity TRICHOSTATIN A factory supply TRICHOSTATIN A
Product Name: | TRICHOSTATIN A |
Synonyms: | 7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6R-DIMETHYL-7-OXO-2E,4E-HEPTADIENAMIDE;4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXAHEPTA-2,4-DIENOHYDROXAMIC ACID;4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXOHEPTA-2,4-DIENOHYDROXAMIC ACID;7-(4-(dimethylamino)phenyl)-n-hydroxy-4,6-dimethyl-7-oxo-4-heptadienamide;TSA;TRICHOSTATIN A;TRICHOSTATIN A, STREPTOMYCES SPECIES;Trichostatin A, Streptomyces sp. |
CAS: | 58880-19-6 |
MF: | C17H22N2O3 |
MW: | 302.37 |
EINECS: | |
Product Categories: | Anti Cancer Research;Inhibitor;antibiotic;API;Inhibitors |
Mol File: | 58880-19-6.mol |
TRICHOSTATIN A Chemical Properties |
Melting point | 140-143℃ |
alpha | D20.5 +62.8° ±1.1° (c = 1.007 in ethanol) |
density | 1.139 |
refractive index | 136 ° (C=0.3, MeOH) |
storage temp. | −20°C |
solubility | ethanol: 1 mg/mL |
Merck | 14,9649 |
Safety Information |
Hazard Codes | Xn,Xi |
Risk Statements | 20/21/22-36/37/38-43 |
Safety Statements | 26-36 |
RIDADR | NA 1993 / PGIII |
WGK Germany | 3 |
RTECS | MI5215000 |
MSDS Information |
Provider | Language |
---|---|
SigmaAldrich | English |
TRICHOSTATIN A Usage And Synthesis |
Chemical Properties | Solid |
Uses | Trichostatin A is a known inhibitor of fibrosis in vitro and in vivo, and is used as an anticancer agent. Potent differentiation inducer of friend leukemic cells. |
Uses | Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumour activity |
Uses | Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumor activity |
Biological Activity | Selective and potent inhibitor of histone deacetylase (K i = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells. |
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