top Betamethasone 2...

top Betamethasone 21-phosphate disodium

top Betamethasone 21-phosphate disodium

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1 Gram

FOB Price: USD 1.0000

  • Min.Order :1 Gram
  • Purity: 99%
  • Payment Terms : L/C,T/T,

Keywords

Betamethasone 21-phosphate disodium high purity Betamethasone 21-phosphate disodium factory supply Betamethasone 21-phosphate disodium

Quick Details

  • Appearance:Colorless to light yellow liquid
  • Application:Used in a base-free iridium-catalyzed direct alkylation of active methylene compounds with alcohols.1
  • PackAge:as you requested
  • ProductionCapacity:10|Kilogram|Day
  • Storage:room temperature
  • Transportation:by courier

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Details:

Product Name: Betamethasone 21-phosphate disodium
Synonyms: 20-dione,9-fluoro-11-beta,17,21-trihydroxy-16-beta-methyl-pregna-4-diene-3;21-(dihydrogenphosphate),disodiumsalt;bentelan;Betamethasone Sodium Phosphate (500 mg)K0C3580.993mg/mg(an);Betamethasone Sodium Phosphate (500 mg);Betamethasone 21-pho;(11β,16β)-9-Fluoro-11,17-dihydroxy-16-Methyl-21-(phosphonooxy)pregna-1,4-diene-3,20-dione SodiuM Salt;9-Fluoro-11β,17,21-trihydroxy-16β-Methylpregna-1,4-diene -3,20-dione 21-(Dihydrogen Phosphate) SodiuM Salt
CAS: 151-73-5
MF: C22H28FNa2O8P
MW: 516.4
EINECS: 205-797-0
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;Steroids;CELESTONE;Betamethasone;Hormones;Steroid Hormones
Mol File: 151-73-5.mol
Betamethasone 21-phosphate disodium Structure
 
Betamethasone 21-phosphate disodium Chemical Properties
Merck  14,1180
EPA Substance Registry System Pregna-1,4-diene- 3,20-dione, 9-fluoro-11,17-dihydroxy-16- methyl-21-(phosphonooxy)-, disodium salt, (11.beta.,16.beta.)-(151-73-5)
 
Safety Information
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
WGK Germany  3
RTECS  TU4056500
MSDS Information
Provider Language
SigmaAldrich English
 
Betamethasone 21-phosphate disodium Usage And Synthesis
Indications and Usage Betamethasone Sodium Phosphate, also called Bentelan, Betnesol, betamethasone phosphate, and celestone phosphate, is an adrenal cortex hormone, an isomer of dexamethasone with the same effects as prednisolone and dexamethasone.
It is mainly used against inflammation and allergies. Its effects are the same as those of dexamethasone, and its anti-inflammatory effects are stronger than dexamethasone, prednisone, and cortisone, with fewer side effects. It is used to treat active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, acute leukemia, allergic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, pruritis, and comprehensively treat some infections.
Mechanisms of Action Betamethasone sodium phosphate has pharmacological effects in treating inflammation, rheumatism, allergies, and immunosuppressive conditions. Its anti-inflammatory effects are stronger than those of dexamethasone, triamcinolone, and hydrocortisone. It can reduce and prevent tissue response to inflammation, partly eliminating non-infectious inflammation caused by fever, redness, and swelling, thereby reducing the presence of swelling. The anti-inflammatory effects of 0.3 mg of betamethasone sodium phosphate are comparable to those of 0.75 mg of dexamethasone, 5 mg of prednisone, or 25 mg of cortisone. Its sodium retention effects are more than a hundred times those of cortisone. In case of primary adrenal hypofunction, together with corticosteroids, it can be used to replace treatment or prevention, or inhibit of cellular immune response, delay allergic reaction, and reduce the extension of the primary immune response, suitable for low renin and low aldosterone syndrome and orthodontic hypotension caused by autonomic neuropathy.
Contraindications Not for use by those with a history of serious mental illness, active duodenum, gastric ulcers, recent gastrointestinal anastomosis, serious osteoporosis, pronounced diabetes, or serious high blood pressure, viruses which cannot be treated by antibiotics, bacterial of fungal infection, thrombophlebitis, or infectious skin diseases such as impetigo, tinea corporis, or tinea cruris.
Category Toxic
Toxicity level Medium
Acute toxicity Oral administration - mice LD50: >4500 mg/kg
Flammability Flammable; produces toxic fluoride fumes
Storage and transport Store in a cool, ventilated, and dry place
Extinguishing agents Dry powder, foam, sand, carbon dioxide, mist
Uses A Betamethasone
Uses antiinflammatory, glucocorticoid
Uses Nasal, Ophthalmic, Oral, Parenteral
Uses An anti-inflammatory agent
Definition ChEBI: An organic sodium salt that is the disodium salt of betamethasone phosphate.

 

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