Desmopressin Acetate supplier Desmopressin wholesale Desmopressin powder
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Description of Desmopressin Acetate: Desmopressin acetate (trade names: DDAVP, Stimate, Minirin) is a synthetic replacement for vasopressin, the hormone that reduces urine production. It may be taken nasally, intravenously, or as a tablet. Doctors prescribe Desmopressin most frequently for treatment of diabetes insipidus or nocturnal enuresis. Desmopressin (1-desamino-8-D-arginine vasopressin) is a modified form of the normal human hormone arginine vasopressin, a peptide containing nine amino acids. Medical use of Desmopressin acetate includes: (a) bed wetting; (b) nighttime urination; (c) clotting disorders; (d) diabetes insipidus .
Test |
Specification |
Result |
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Appearance |
White or almost white fluffy powder |
conforms |
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Solubility
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Soluble in water, in ethanol(96%) and in glacial acetic acid |
conforms |
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HPLC |
The principal peak in the chromatogram obtained with the test solution is similar in retention time to principal peak in the chromatogram obtained with the reference solution. |
conforms |
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Water |
NMT 6.0% |
4.5% |
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Amino acid analysis |
Amino acid limits
No more than the traces of other amino acids are present. |
Amino acid limits
conforms |
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Related Substances (purity) |
Unspecified impurity for each impurity: NMT0.5%
Total impurity: NMT 1.5% |
0.35%(single largest impurity)
1.20% |
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Acetic acid |
3.0%~8.0% |
5.3% |
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MS |
1069.22±1.0 |
1068.6 |
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Bacterial Endotoxins |
Less than 500IU/mg |
conforms |
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Assay |
95.0%-105.0% (anhydrous and acetic acid free subtance) |
98.7% |
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Specific Optical Rotation (c=0.2, 1% aceticacid) |
-72° to -82° (anhydrous and acetic acid free substance) |
-76.3° |
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Residual solvent |
Methanol:NMT 3000ppm Acetonitrile:NMT 410 ppm Triethylamine:NMT 320 ppm |
conforms |
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