Newblue-CHEM - Met...

Newblue-CHEM - Metoprolol tartrate

Newblue-CHEM - Metoprolol tartrate

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1 Gram

FOB Price: USD 1000.0000

  • Min.Order :1 Gram
  • Purity: 99.0%
  • Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Metoprolol tartrate 56392-17-7 2C15H25NO3.C4H6O6

Quick Details

  • Appearance:Solid
  • Application:Organic synthesis
  • PackAge:IN 25kg drums
  • ProductionCapacity:10|Metric Ton|Month
  • Storage:In Room Temperature
  • Transportation:As per MSDS

Superiority:

Henan Newblue Chemical Co., Ltd. is located in Zhengzhou High-tech Development Zone with import and export license.

We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013.The objective of the company is to put quality first and put our customer’s needs first - the satisfaction of our customers is the company's ultimate goal.

Improving product quality and service level is our responsibility, and creating more value for our customer’s is our purpose. We are constantly striving to make Henan Newblue a leading chemical supplier, and hope to create a better future with you.

Details:

Metoprolol tartrate Basic information
β1 receptor blocker Uses Hazards & Safety Information
Product Name: Metoprolol tartrate
Synonyms: Metoprolol tar;1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol, (2R,3R)-2,3-dihydroxybutanedioate (2:1);Metoprolol tartrate solution;Metoprolol tartrate, >=99%;1-(Isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol hemi((2R,3R)-2,3-dihydroxysuccinate);Metoprolol Tartrat;(±)1-(Isopropylamino)-3-[p-(β-methoxyethyl)phenoxy]-2-propanol tartrate salt Lopressor 1-(Isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol (2:1) Dextro-tartrate salt;(+-)-1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanolhemi-l-tartr
CAS: 56392-17-7
MF: 2C15H25NO3.C4H6O6
MW: 684.82
EINECS: 260-148-9
Product Categories: Cardiovascular APIs;Cardiovascular;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Adrenoceptor;UROXATRAL
Mol File: 56392-17-7.mol
Metoprolol tartrate Structure
Metoprolol tartrate Chemical Properties
Melting point 120℃
Fp 9℃
storage temp. Desiccate at RT
solubility H2O: soluble50mg/mL
color white to off-white
Water Solubility Soluble in water (>1000 mg/ml), methanol (>500 mg/ml), chloroform (496 mg/ml), ethanol (31 mg/ml at 25°C), and DMSO (100 mg/ml at 25°C).
λmax 223nm(H2O)(lit.)
Merck 14,6151
Stability: Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference 56392-17-7(CAS DataBase Reference)
Safety Information
Hazard Codes F,T
Risk Statements 11-23/24/25-39/23/24/25
Safety Statements 7-16-36/37-45-24/25
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
RTECS UB7450100
MSDS Information
Provider Language
1-(Isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-2-propanol (2:1) Dextro-tartrate salt English
Metoprolol tartrate Usage And Synthesis
β1 receptor blocker Metoprolol tartrate is a selective β1-adrenergic receptor blocker,oral absorption is rapid  and complete,it is used for the treatment of hypertension, angina pectoris, myocardial infarction, hypertrophic cardiomyopathy, aortic dissection, cardiac arrhythmia, hyperthyroidism, cardiac neurosis and other diseases. In recent years, it is also used for ther treatment of heart failure, which can reduce mortality. In unstable/non-ST-segment elevation myocardial infarction and acute myocardial infarction  control guiding principles developed by American Heart Association , effect of metoprolol tartrateare is clearly recognized. In the past, concerns about β-blocker therapy caused hypotension is too large, and for the consideration that there may be racial differences between Asians in β-blocker use and the West, patients with treatment of β-blockers in China is  fewer  , the use of β-blockers is in lower dose.
Metoprolol tartrate has a weaker membrane stability and it has no intrinsic sympathomimetic activity, and in comparison with similar drugs commonly used in clinical propranolol ,in addition to the advantages of β1-blocker on its pharmacodynamic,it also has its pharmacokinetic kinetics  advantages, such as relatively weak first-pass effect compared with propranolol, simple metabolic pathways, most pharmacologically inactive metabolites and the like.
Uses Hypertensive medication.
Hazards & Safety Information Category: toxic substances
Toxicity grading: Middle  poisoning
Acute toxicity: oral -rat LD50: 5500 mg/kg; Oral-Mouse LD50: 1500 mg/kg
Flammability and hazard characteristics: It is combustible; fire decomposition produces toxic nitrogen oxide gases
Storage Characteristics: Ventilated, low-temperature ,dry storeroom.
Extinguishing agent: Water, carbon dioxide, dry powder, sandy soil.
Chemical Properties Crystalline Powder
Uses A selective aryloxypropanolamine andrenergic antagonist. Used in the treatment of a variety of cardiovascular disorder. Antihypertensive; antianginal; antiarrhythmic (class II)
Uses A β1 selective aryloxypropanolamine andrenergic antagonist. Used in the treatment of a variety of cardiovascular disorder. Antihypertensive; antianginal; antiarrhythmic (class II).
Uses alpha(1)-adrenergic blocker
Uses A b1-Adrenergic blocker
Biological Activity Selective β 1 -adrenoceptor antagonist (K i values are 47, 2960 and 10100 nM for β 1 , β 2 and β 3 adrenoceptors respectively). Inhibits spontaneous endothelin-1 production in vitro and displays antihypertensive and antianginal activity in vivo .
Metoprolol tartrate Preparation Products And Raw materials

 

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