Nevirapine Basic information
Product Name: Nevirapine
Synonyms: 6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-;5-CYCLOPROPYL-9-METHYL-5,10-DIHYDRO-4,5,6,10-TETRAAZA-DIBENZO[A,D]CYCLOHEPTEN-11-ONE;VIRAMUNE;NEVIRAPINE;Novirapine*;Nevirapine(Nvp);NEVIRAPINE(SUBJECTTOPATENTFREE);11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2’,3’-][1,4] diazepin-6-one
CAS: 129618-40-2
MF: C15H14N4O
MW: 266.3
EINECS:
Product Categories: Active Pharmaceutical Ingredients;API;Anti-virals;Inhibitors;Intermediates & Fine Chemicals;Non-nucleoside Reverse Transcriptase;Pharmaceuticals;Other APIs
Mol File: 129618-40-2.mol
Nevirapine Structure
Nevirapine Chemical Properties
Melting point 247°C
Fp 9℃
storage temp. -20°C Freezer
solubility DMSO: ≥22mg/mL
pka 2.8(at 25℃)
color white to tan
Merck 14,6490
CAS DataBase Reference 129618-40-2(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-37/39
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
RTECS JM5562500
Hazardous Substances Data 129618-40-2(Hazardous Substances Data)
MSDS Information
Provider Language
11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one English
Nevirapine Usage And Synthesis
Chemical Properties Crystalline Solid
Uses amyloidosis therapy
Uses Labelled Nevirapine , a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Antiviral.;Labeled Nevirapine, intended for use as an internal standard for the quantification of Nevirapine by GC- or LC-mass spectrometry.
Uses A potent (IC50=84nM) and selective non-nucleoside inhibitorf HIV-1 reverse transcriptase
Definition ChEBI: A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse tr nscriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection.
Nevirapine Preparation Products And Raw materials
Raw materials N,N-Dimethylformamide-->2-Chloro-3-amino-4-methyl pyridine-->2-Chloronicotinyl chloride-->NETOBIMIN-->2-Hydroxy-4-methyl-3-nitropyridine