Feed Additives Azaperone CAS 1649-18-9 for Animal Cell Synthesis Blocker

Feed Additives Azaperone CAS 1649-18-9 for Animal Cell Synthesis Blocker

Product Name: Azaperone
Synonyms: AZAPERON;AZAPERONE;1-(4-FLUOROPHENYL)-4-[4-(2-PYRIDINYL)-1-PIPERAZINYL]-1-BUTANONE;1-(4-FLUORO-PHENYL)-4-(4-PYRIDIN-2-YL-PIPERAZIN-1-YL)-BUTAN-1-ONE;1-(3-(4-Fluorobenzoyl)propyl)-4-(2-pyridyl)piperazine;1-(4-fluorophenyl)-4-(4-(2-pyridinyl)-1-piperazinyl)-1-butanon;1-Butanone, 1-(4-fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-;4’-fluoro-4-(4-(2-pyridyl)-1-piperazinyl)-butyrophenon
CAS: 1649-18-9
MF: C19H22FN3O
MW: 327.4
EINECS: 216-715-8

Azaperone Usage And Synthesis

Chemical Properties Off-White Solid
Usage H1 antihistamine (nonsedating); leucotriene synthesis blocker
Usage Sedative; tranquilizer.
Definition ChEBI: An N-arylpiperazine that is 2-(piperazin-1-yl)pyridine in which the amino hydrogen is replaced by a 3-(4-fluobenzoyl)propyl group. Used mainly as a tranquiliser for pigs and elephants.

Azaperone Veterinary use

Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. It is uncommonly used in humans as an antipsychotic drug.

Azaperone acts primarily as a dopamine antagonist but also has some antihistaminic and anticholinergic properties as seen with similar drugs such as haloperidol. Azaperone may cause hypotension and while it has minimal effects on respiration in pigs, high doses in humans can cause respiratory depression.

The most common use for azaperone is in relatively small doses to reduce aggression in farmed pigs, either to stop them fighting or to encourage sows to accept piglets. Higher doses are used for anesthesia in combination with other drugs such as xylazine, tiletamine and zolazepam. Azaperone is also used in combination with strong narcotics such as etorphine or carfentanil for tranquilizing large animals such as elephants. Use in horses is avoided as adverse reactions may occur.

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