SB 525334; 6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline

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1 Gram	Negotiable

1 Gram

Negotiable

Min.Order :1 Gram
Purity: 98%
Payment Terms : T/T,,MoneyGram,Other

Keywords

356559-20-1 SB 525334 SB525334

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Application:For research only.
PackAge:as required
ProductionCapacity:100|Gram|Month
Storage:
Transportation:Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

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Details:

CAS No.：356559-20-1

LAL ID：xqy-170107

Chemical Names: 356559-20-1; SB 525334; 6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline

Molecular Formula: C21H21N5

Molecular Weight: 343.434 g/mol

Purity: 98%

Description:

Potent and selective inhibitor of the ALK5 receptor (IC50 value 14.3 nM). SB 525334 is approximately 4-fold less potent as an inhibitor of ALK4, and inactive as an inhibitor of ALK2, ALK3, and ALK6. In cell-based assays, SB 525334 blocked TGF-β1-induced phosphorylation and nuclear translocation of Smad2/3 in renal proximal tubule cells and inhibited TGF-β1-induced increases in plasminogen activator inhibitor-1 (PAI-1) and procollagen alpha1(I) mRNA expression in renal epithelial carcinoma cells.

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