HS-173; Ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate

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1 Gram	Negotiable

1 Gram

Negotiable

Min.Order :1 Gram
Purity: 98%
Payment Terms : T/T,,MoneyGram,Other

Keywords

1276110-06-5 HS-173 Ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate

Quick Details

Appearance:white solid powder
Application:For research only.
PackAge:as required
ProductionCapacity:100|Gram|Month
Storage:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Transportation:Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

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Details:

CAS No.：1276110-06-5

LAL ID：xqy-170108

Chemical Names: HS-173; Ethyl 6-(5-(phenylsulfonamido)pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxylate

Molecular Formula: C21H18N4O4S

Molecular Weight: 422.459 g/mol

Purity: 98%

The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%.

Description: HS-173 is a potent PI3Kα inhibitor with potential anticancer activity. HS-173 inhibited the PI3K signaling pathway, and showed anti-proliferative effects on cancer cells. Also, HS-173 induced cell cycle arrest at the G(2)/M phase and apoptosis. In addition, HS-173 decreased the expression HIF-1α and VEGF which play an important role in angiogenesis. This effect was confirmed by the suppression of tube formation and migration assay in vitro. Furthermore, HS-173 diminished blood vessel formation in the Matrigel plug assay in mice. Therefore, HS-173 is considered as a novel drug candidate to treat cancer patients.

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