SGC707

Min.Order / FOB Price:Get Latest Price

1 Gram	Negotiable

1 Gram

Negotiable

Min.Order :1 Gram
Purity: 98%
Payment Terms : T/T,Other

Keywords

1687736-54-4 SGC707 C16H18N4O2

Quick Details

Appearance:solid powder
Application:For research only.
PackAge:as required
ProductionCapacity:100|Gram|Month
Storage:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Transportation:Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Superiority:

SGC707, purity > 98%, is in not stock. This is our mature product with high quality and competitive price. Welcome to order it as well as customized it. Also, we would like to develop strategic partnership with our clients.

Note: We only provide quotation to customers who disclose their organization detail. We must know who will use the product since we do not sell products for human and household use. Inquiries without enough detail contact information will be ignored. Quotation of custom synthesis is only provided through email, will not be provided through phone.

Details:

CAS No.：1687736-54-4

LAL ID：xqy-170112

Chemical Names: SGC707; 1687736-54-4.

Molecular Formula: C16H18N4O2

Molecular Weight: 298.346 g/mol

Purity: 98%

The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%.

Description: SGC707 is a potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase?3 (PRMT3). SGC707 is a potent PRMT3 inhibitor (IC50 =31±2?nM, KD =53±2?nM) with outstanding selectivity (selective against 31 other methyltransferases and more than 250 non-epigenetic targets). The mechanism of action studies and crystal structure of the PRMT3-SGC707 complex confirm the allosteric inhibition mode. Importantly, SGC707 engages PRMT3 and potently inhibits its methyltransferase activity in cells. It is also bioavailable and suitable for animal studies. This well-characterized chemical probe is an excellent tool to further study the role of PRMT3 in health and disease.

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