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142217-69-4 Entecavir Baraclude
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Entecavir Oral Antiviral Raw Materia Drug CAS 142217-69-4 Treatment of Hepatitis B
Quick detail
Entecavir | ||
CAS No.: | 142217-69-4 | |
Synonyms: | 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one; Baraclude; UNII-NNU2O4609D; Entecavir(anhydrous); | |
Formula: | C12H15N5O3 | |
Exact Mass: | 277.11700 | |
Molecular Weight: | 277.27900 | |
PSA: | 130.05000 | |
LogP: | -0.24660 | |
Properties | ||
Appearance | white to off-white/yellow crystalline powder | |
Density: | 1.81g/cm3 | |
Melting Point: | 249-252ºC | |
Boiling Point: | 734.2ºC at 760 mmHg | |
Flash Point: | 397.9ºC | |
Refractive Index: | 1.837 |
Entecavir Description
Entecavir INN, abbreviated ETV, is an oral antiviral drug used in the treatment of hepatitis B virus (HBV) infection. Entecavir is a reverse transcriptase inhibitor. It prevents the hepatitis B virus from multiplying and reduces the amount of virus in the body. More specifically, it is a deoxyguanosine analogue belonging to a class of carbocyclic nucleosides, that inhibits reverse transcription, DNA replication and transcription in the viral replication process.
Entecavir is used for
Treating HBV infection in certain patients.
Entecavir is a nucleoside analogue. It works by reducing the amount of HBV in the blood. It also helps prevent the HBV from multiplying and infecting new liver cells.
Do NOT use entecavir if
you are allergic to any ingredient in entecavir
you have HIV infection and you are not receiving HAART
Contact your doctor or health care provider right away if any of these apply to you.
Entecavir Dosage
Recommended dosage: adult and over the age of 16 young oral this product, once a day, each 0.5 mg. lamivudine treatment viremia or patients with lamivudine resistant mutants to once a day, each 1.0 mg (0.5mg two pieces), taken on an empty stomach (a meal or a meal after at least 2 hours).
How Does Entecavir Work
Entecavir is a reverse transcriptase inhibitor that works by preventing the hepatitis B virus from multiplying and thereby decreasing the amount of the virus in the body.
However, it is important to note that entecavir is not a cure for HBV and it may not prevent damage to the liver or reduce the chances of developing liver cancer. In addition, entecavir doesn't prevent the spread of HBV to others through the normal routes of transmission, including sexual contact or exposure to blood or bodily fluids.
Side Effects of Entecavir
As with all drugs, there are some risks to taking entecavir. Some are more serious than others.
Lactic Acidosis |
In rare cases, entecavir can cause a condition known as lactic acidosis, which is a build-up of lactic acid in the body. This condition can come on insidiously and worsen over time, therefore even mild symptoms warrant seeking emergency medical help.
|
Symptoms of lactic acidosis include: |
Muscle pain and/or weakness
A numb or cold feeling in the limbs Difficulty breathing Feeling dizzy, light-headed, tired, or very weak Stomach pain, nausea or vomiting Slow or uneven heart rate |
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