Quick Detail:
Product Name | Erlotinib hydrochloride |
CAS | 183319-69-9 |
MF | C22H24ClN3O4 |
MW | 429.9 |
Chemical Properties | Off-White Solid |
Usage |
Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor. Antineoplastic Erlotinib HCl is an HER1/EGFR inhibitor with IC50 of 2 nM. Erlotinib HCl (OSI-744) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Phase 3. |
Applications:
Erlotinib hydrochloride is a kind of small molecule EGFR tyrosine kinase reversible inhibitor, is mainly used for the treatment of locally advanced or metastatic non small cell lung cancer second-line or three line treatment and pancreatic cancer.
Erlotinib hydrochloride Specification:
1 | Appearance | White or off-white powder | Conforms |
2 | Identification | ||
|
a) IR | IR chromatograph Conforms to the characteristic peak of R.S. | Conforms |
|
b) HPLC | The retention time of the major peak in the chromatogram Conforms to the characteristic peak of R.S. | Conforms |
3 | Residue on ignition | Not more than 0.1% | 0.07% |
4 | Loss on drying | Not more than 0.5% | 0.38% |
5 | Heavy Metals | Not more than 20 ppm | Conforms |
6 | Related substance |
|
|
7 |
Single impurity | Not more than 0.15% | 0.13% |
8 |
Total impurities | Not more than 1.0% | 0.56% |
9 | Purity[HPLC] | Not less than 99.0% | 99.44% |
10 | Assay(caculated on anhydrous basis) | 98.5%~101.5% |
99.3% |