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508233-74-7 Vortioxetine Lu AA21004
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New Improving Mood Raw Material Drug Vortioxetine Lu AA21004 HBr CAS 508233-74-7
Quick detail
Product Name: Vortioxetine
Synonyms: 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine;Lu AA 21004;Vortioxetine;1-(2-((2,4-DiMethylphenyl)thio)phenyl)piperazine;Trintellix (vortioxetine);Vortioxetine(Lu AA21004);1-(2-((2,4-DIMETHYLPHENYL)THIO)PHENYL)PIPERAZINE-HCL;Vortioxetin
CAS: 508233-74-7
MF: C18H22N2S
MW: 298.44568
PSA: 40.57000
LogP: 4.25800
Product Categories: 5-HT antagonist;Serotonin transporter inhibitor;Inhibitors
Vortioxetine Description
Vortioxetine (Brintellix) is an antidepressant that works through serotonin reuptake inhibition and direct receptor activity, acting as both a serotonin receptor agonist and antagonist.1 It is labeled for the treatment of major depressive disorder in adults.
Trintellix (Vortioxetine) is a new type of serotonin modulating antidepressant that can be tried when the other antidepressants don't work, but some people may find the side effects intolerable and the cost expensive.
Vortioxetine Usage
Vortioxetine Recomended Dose
PO: (Adults) 10 mg once daily initially, may be ↑ to 20 mg once daily; some patients may only tolerate daily doses of 5 mg; CYP2D6 poor metabolizers– daily dose should not exceed 10 mg; Concurrent use of inhibitors of CYP2D6– ↓ dose by 50%; Concurrent use of strong inducers of CYP2D6 for more than 14 days– consider ↑ dose (not to exceed three times original dose). If daily dose 15–20 mg/day, do not discontinue abruptly; taper to 10 mg/day for one week before discontinuing.
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